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@ARTICLE{Nguyen:844590,
author = {Nguyen, Trung Hai and Zhang, Chao and Weichselbaum, Ewald
and Knyazev, Denis G. and Pohl, Peter and Carloni, Paolo},
title = {{I}nterfacial water molecules at biological membranes:
{S}tructural features and role for lateral proton diffusion},
journal = {PLoS one},
volume = {13},
number = {2},
issn = {1932-6203},
address = {Lawrence, Kan.},
publisher = {PLoS},
reportid = {FZJ-2018-01994},
pages = {e0193454 -},
year = {2018},
abstract = {Proton transport at water/membrane interfaces plays a
fundamental role for a myriad of bioenergetic processes.
Here we have performed ab initio molecular dynamics
simulations of proton transfer along two phosphatidylcholine
bilayers. As found in previous theoretical studies, the
excess proton is preferably located at the water/membrane
interface. Further, our simulations indicate that it
interacts not only with phosphate head groups, but also with
water molecules at the interfaces. Interfacial water
molecules turn out to be oriented relative to the lipid
bilayers, consistently with experimental evidence. Hence,
the specific water-proton interaction may help explain the
proton mobility experimentally observed at the membrane
interface.},
cin = {IAS-5 / INM-9},
ddc = {500},
cid = {I:(DE-Juel1)IAS-5-20120330 / I:(DE-Juel1)INM-9-20140121},
pnm = {574 - Theory, modelling and simulation (POF3-574)},
pid = {G:(DE-HGF)POF3-574},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:29474432},
UT = {WOS:000426049500110},
doi = {10.1371/journal.pone.0193454},
url = {https://juser.fz-juelich.de/record/844590},
}