% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Dafsari:844794,
      author       = {Dafsari, Haidar Salimi and Petry-Schmelzer, Jan Niklas and
                      Ray-Chaudhuri, K. and Ashkan, Keyoumars and Weis, Luca and
                      Dembek, Till A. and Samuel, Michael and Rizos, Alexandra and
                      Silverdale, Monty and Barbe, Michael T. and Fink, Gereon R.
                      and Evans, Julian and Martinez-Martin, Pablo and Antonini,
                      Angelo and Visser-Vandewalle, Veerle and Timmermann, Lars},
      title        = {{N}on-motor outcomes of subthalamic stimulation in
                      {P}arkinson's disease depend on location of active contacts},
      journal      = {Brain stimulation},
      volume       = {11},
      number       = {4},
      issn         = {1876-4754},
      address      = {New York, NY [u.a.]},
      publisher    = {Elsevier},
      reportid     = {FZJ-2018-02170},
      pages        = {904-912},
      year         = {2018},
      abstract     = {BackgroundSubthalamic nucleus (STN) deep brain stimulation
                      (DBS) improves quality of life (QoL), motor, and non-motor
                      symptoms (NMS) in Parkinson's disease (PD). Few studies have
                      investigated the influence of the location of
                      neurostimulation on NMS.ObjectiveTo investigate the impact
                      of active contact location on NMS in STN-DBS in PD.MethodsIn
                      this prospective, open-label, multicenter study including 50
                      PD patients undergoing bilateral STN-DBS, we collected
                      NMSScale (NMSS), NMSQuestionnaire (NMSQ), Hospital Anxiety
                      and Depression Scale (anxiety/depression, HADS-A/-D),
                      PDQuestionnaire-8 (PDQ-8), Scales for Outcomes in PD-motor
                      examination, motor complications, activities of daily living
                      (ADL), and levodopa equivalent daily dose (LEDD)
                      preoperatively and at 6 months follow-up. Changes were
                      analyzed with Wilcoxon signed-rank/t-test and
                      Bonferroni-correction for multiple comparisons. Although the
                      STN was targeted visually, we employed an atlas-based
                      approach to explore the relationship between active contact
                      locations and DBS outcomes. Based on fused MRI/CT-images, we
                      identified Cartesian coordinates of active contacts with
                      patient-specific Mai-atlas standardization. We computed
                      linear mixed-effects models with x-/y-/z-coordinates as
                      independent, hemispheres as within-subject, and test change
                      scores as dependent variables.ResultsNMSS, NMSQ, PDQ-8,
                      motor examination, complications, and LEDD significantly
                      improved at follow-up. Linear mixed-effect models showed
                      that NMS and QoL improvement significantly depended on more
                      medial (HADS-D, NMSS), anterior (HADS-D, NMSQ, PDQ-8), and
                      ventral (HADS-A/-D, NMSS, PDQ-8) neurostimulation. ADL
                      improved more in posterior, LEDD in lateral neurostimulation
                      locations. No relationship was observed for motor
                      examination and complications scores.ConclusionsOur study
                      provides evidence that more anterior, medial, and ventral
                      STN-DBS is significantly related to more beneficial
                      non-motor outcomes.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29655586},
      UT           = {WOS:000436849700030},
      doi          = {10.1016/j.brs.2018.03.009},
      url          = {https://juser.fz-juelich.de/record/844794},
}