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000844795 245__ $$aNeocortical electrical stimulation for epilepsy: Closed-loop versus open-loop
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000844795 520__ $$aThe aim of this review is to evaluate whether open-loop or closed-loop neocortical electrical stimulation should be the preferred approach to manage seizures in intractable epilepsy.Twenty cases of open-loop neocortical stimulation with an implanted device have been reported, in 5 case studies. Closed-loop stimulation with an implanted device has been investigated in a larger number of patients in the RNS System clinical trials. With 230 patients enrolled at the start of the Long-term Treatment Trial, 115 remained at the last reported follow-up. Open-loop stimulation reduced seizure frequency in patients on average with over 90% compared to baseline. Closed-loop stimulation reduces seizure frequency with 60%–65%.Even though open-loop neocortical electrical stimulation has only been reported in 20 patients, and closed-loop in much a larger sample, evidence suggests that both approaches are effective in reducing seizures. It remains an open question which should be clinically preferred. Therefore, a head-to-head adaptive clinical study comparing both approaches is proposed
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000844795 7001_ $$00000-0002-7998-414X$$avan Blooijs, Dorien$$b1$$eCorresponding author
000844795 7001_ $$0P:(DE-HGF)0$$aLeijten, Frans$$b2
000844795 7001_ $$0P:(DE-HGF)0$$aHuiskamp, Geertjan$$b3
000844795 773__ $$0PERI:(DE-600)2013048-X$$a10.1016/j.eplepsyres.2018.02.010$$gVol. 141, p. 95 - 101$$p95 - 101$$tEpilepsy research$$v141$$x0920-1211$$y2018
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000844795 8564_ $$uhttps://juser.fz-juelich.de/record/844795/files/Vassileva_2018_Post%20Print_Epilepsy%20Res_Neocortical%20electrical%20stimulation%20for%20epilepsy.pdf$$yPublished on 2018-02-16. Available in OpenAccess from 2019-02-16.
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