TY  - JOUR
AU  - Vassileva, Albena
AU  - van Blooijs, Dorien
AU  - Leijten, Frans
AU  - Huiskamp, Geertjan
TI  - Neocortical electrical stimulation for epilepsy: Closed-loop versus open-loop
JO  - Epilepsy research
VL  - 141
SN  - 0920-1211
CY  - Amsterdam [u.a.]
PB  - Elsevier89326
M1  - FZJ-2018-02171
SP  - 95 - 101
PY  - 2018
AB  - The aim of this review is to evaluate whether open-loop or closed-loop neocortical electrical stimulation should be the preferred approach to manage seizures in intractable epilepsy.Twenty cases of open-loop neocortical stimulation with an implanted device have been reported, in 5 case studies. Closed-loop stimulation with an implanted device has been investigated in a larger number of patients in the RNS System clinical trials. With 230 patients enrolled at the start of the Long-term Treatment Trial, 115 remained at the last reported follow-up. Open-loop stimulation reduced seizure frequency in patients on average with over 90% compared to baseline. Closed-loop stimulation reduces seizure frequency with 60%–65%.Even though open-loop neocortical electrical stimulation has only been reported in 20 patients, and closed-loop in much a larger sample, evidence suggests that both approaches are effective in reducing seizures. It remains an open question which should be clinically preferred. Therefore, a head-to-head adaptive clinical study comparing both approaches is proposed
LB  - PUB:(DE-HGF)16
C6  - pmid:29547789
UR  - <Go to ISI:>//WOS:000430781700013
DO  - DOI:10.1016/j.eplepsyres.2018.02.010
UR  - https://juser.fz-juelich.de/record/844795
ER  -