Home > Publications database > Neocortical electrical stimulation for epilepsy: Closed-loop versus open-loop > print

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024 7 _ |a 10.1016/j.eplepsyres.2018.02.010
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100 1 _ |a Vassileva, Albena
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245 _ _ |a Neocortical electrical stimulation for epilepsy: Closed-loop versus open-loop
260 _ _ |a Amsterdam [u.a.]
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520 _ _ |a The aim of this review is to evaluate whether open-loop or closed-loop neocortical electrical stimulation should be the preferred approach to manage seizures in intractable epilepsy.Twenty cases of open-loop neocortical stimulation with an implanted device have been reported, in 5 case studies. Closed-loop stimulation with an implanted device has been investigated in a larger number of patients in the RNS System clinical trials. With 230 patients enrolled at the start of the Long-term Treatment Trial, 115 remained at the last reported follow-up. Open-loop stimulation reduced seizure frequency in patients on average with over 90% compared to baseline. Closed-loop stimulation reduces seizure frequency with 60%–65%.Even though open-loop neocortical electrical stimulation has only been reported in 20 patients, and closed-loop in much a larger sample, evidence suggests that both approaches are effective in reducing seizures. It remains an open question which should be clinically preferred. Therefore, a head-to-head adaptive clinical study comparing both approaches is proposed
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700 1 _ |a van Blooijs, Dorien
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700 1 _ |a Leijten, Frans
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700 1 _ |a Huiskamp, Geertjan
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773 _ _ |a 10.1016/j.eplepsyres.2018.02.010
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856 4 _ |y Published on 2018-02-16. Available in OpenAccess from 2019-02-16.
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856 4 _ |y Published on 2018-02-16. Available in OpenAccess from 2019-02-16.
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