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@ARTICLE{Richter:844816,
author = {Richter, Monika and Amunts, Katrin and Mohlberg, Hartmut
and Bludau, Sebastian and Eickhoff, Simon and Zilles, Karl
and Caspers, Svenja},
title = {{C}ytoarchitectonic segregation of human posterior
intraparietal and adjacent parieto-occipital sulcus and its
relation to visuomotor and cognitive functions},
journal = {Cerebral cortex},
volume = {29},
number = {3},
issn = {1047-3211},
address = {Oxford},
publisher = {Oxford Univ. Press},
reportid = {FZJ-2018-02190},
pages = {1305–1327},
year = {2019},
abstract = {Human posterior intraparietal sulcus (pIPS) and adjacent
posterior wall of parieto-occipital sulcus (POS) are
functionally diverse, serving higher motor, visual and
cognitive functions. Its microstructural basis, though, is
still largely unknown. A similar or even more pronounced
architectonical complexity, as described in monkeys, could
be assumed. We cytoarchitectonically mapped the pIPS/POS in
10 human postmortem brains using an observer-independent,
quantitative parcellation. 3D-probability maps were
generated within MNI reference space and used for functional
decoding and meta-analytic coactivation modeling based on
the BrainMap database to decode the general
structural–functional organization of the areas. Seven
cytoarchitectonically distinct areas were identified: five
within human pIPS, three on its lateral (hIP4-6) and two on
its medial wall (hIP7-8); and two (hPO1, hOc6) in POS.
Mediocaudal areas (hIP7, hPO1) were predominantly involved
in visual processing, whereas laterorostral areas (hIP4-6,
8) were associated with higher cognitive functions, e.g.
counting. This shift was mirrored by systematic changes in
connectivity, from temporo-occipital to premotor and
prefrontal cortex, and in cytoarchitecture, from prominent
Layer IIIc pyramidal cells to homogeneous neuronal
distribution. This architectonical mosaic within human
pIPS/POS represents a structural basis of its functional and
connectional heterogeneity. The new 3D-maps of the areas
enable dedicated assessments of structure–function
relationships.},
cin = {INM-1 / INM-7},
ddc = {610},
cid = {I:(DE-Juel1)INM-1-20090406 / I:(DE-Juel1)INM-7-20090406},
pnm = {571 - Connectivity and Activity (POF3-571) / SMHB -
Supercomputing and Modelling for the Human Brain
(HGF-SMHB-2013-2017) / HBP SGA1 - Human Brain Project
Specific Grant Agreement 1 (720270) / HBP SGA2 - Human Brain
Project Specific Grant Agreement 2 (785907)},
pid = {G:(DE-HGF)POF3-571 / G:(DE-Juel1)HGF-SMHB-2013-2017 /
G:(EU-Grant)720270 / G:(EU-Grant)785907},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:30561508},
UT = {WOS:000462494100030},
doi = {10.1093/cercor/bhy245},
url = {https://juser.fz-juelich.de/record/844816},
}