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@ARTICLE{Werner:844893,
      author       = {Werner, Marco and Auth, Thorsten and Beales, Paul A. and
                      Fleury, Jean Baptiste and Höök, Fredrik and Kress, Holger
                      and Van Lehn, Reid C. and Müller, Marcus and Petrov, Eugene
                      P. and Sarkisov, Lev and Sommer, Jens-Uwe and Baulin,
                      Vladimir A.},
      title        = {{N}anomaterial interactions with biomembranes: {B}ridging
                      the gap between soft matter models and biological context},
      journal      = {Biointerphases},
      volume       = {13},
      number       = {2},
      issn         = {1559-4106},
      address      = {Melville, NY},
      publisher    = {AIP},
      reportid     = {FZJ-2018-02235},
      pages        = {028501},
      year         = {2018},
      abstract     = {Synthetic polymers, nanoparticles, and carbon-based
                      materials have great potential in applications including
                      drug delivery, gene transfection, in vitro and in vivo
                      imaging, and the alteration of biological function. Nature
                      and humans use different design strategies to create
                      nanomaterials: biological objects have emerged from billions
                      of years of evolution and from adaptation to their
                      environment resulting in high levels of structural
                      complexity; in contrast, synthetic nanomaterials result from
                      minimalistic but controlled design options limited by the
                      authors' current understanding of the biological world. This
                      conceptual mismatch makes it challenging to create synthetic
                      nanomaterials that possess desired functions in biological
                      media. In many biologically relevant applications,
                      nanomaterials must enter the cell interior to perform their
                      functions. An essential transport barrier is the
                      cell-protecting plasma membrane and hence the understanding
                      of its interaction with nanomaterials is a fundamental task
                      in biotechnology. The authors present open questions in the
                      field of nanomaterial interactions with biological
                      membranes, including: how physical mechanisms and molecular
                      forces acting at the nanoscale restrict or inspire design
                      options; which levels of complexity to include next in
                      computational and experimental models to describe how
                      nanomaterials cross barriers via passive or active
                      processes; and how the biological media and protein corona
                      interfere with nanomaterial functionality. In this
                      Perspective, the authors address these questions with the
                      aim of offering guidelines for the development of
                      next-generation nanomaterials that function in biological
                      media.},
      cin          = {ICS-2},
      ddc          = {570},
      cid          = {I:(DE-Juel1)ICS-2-20110106},
      pnm          = {551 - Functional Macromolecules and Complexes (POF3-551)},
      pid          = {G:(DE-HGF)POF3-551},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29614862},
      UT           = {WOS:000429011800001},
      doi          = {10.1116/1.5022145},
      url          = {https://juser.fz-juelich.de/record/844893},
}