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@ARTICLE{Yu:844894,
      author       = {Yu, Qingfen and Othman, Sameh and Dasgupta, Sabyasachi and
                      Auth, Thorsten and Gompper, Gerhard},
      title        = {{N}anoparticle wrapping at small non-spherical vesicles:
                      curvatures at play},
      journal      = {Nanoscale},
      volume       = {10},
      number       = {14},
      issn         = {2040-3372},
      address      = {Cambridge},
      publisher    = {RSC Publ.},
      reportid     = {FZJ-2018-02236},
      pages        = {6445 - 6458},
      year         = {2018},
      abstract     = {Nanoparticles in biological systems encounter lipid-bilayer
                      membranes as barriers. They interact with plasma membranes,
                      membranous organelles, such as the endoplasmic reticulum and
                      the Golgi apparatus, the nucleus, and intracellular and
                      extracellular vesicles, such as autophagosomes, lysosomes,
                      and exosomes. Extracellular vesicles have recently attracted
                      particular attention, as they are involved in the
                      transmission of biological signals and as regulators for
                      biological processes. For example, exosomes, small vesicles
                      containing proteins, mRNA, and miRNA, that are released by
                      cells into the extracellular environment, have been
                      suggested to participate in tumor metastasis. Furthermore,
                      vesicles can be applied as targeted-drug-delivery systems.
                      We systematically characterize wrapping of spherical
                      nanoparticles that enter and exit vesicles, depending on
                      particle size, vesicle size, vesicle reduced volume, and
                      membrane spontaneous curvature. We predict the complex
                      wrapping behavior, in particular for large
                      particle-to-vesicle size ratios, where the shape changes of
                      the free membrane contribute significantly to the
                      deformation energy and where nanoparticle wrapping
                      transitions and vesicle shape transitions are coupled.
                      Partial-wrapped membrane-bound particles impose boundary
                      conditions on the membrane that stabilise oblates and
                      stomatocytes for particle entry, and prolates and
                      stomatocytes for particle exit. Our results suggest that
                      nanoparticles may stimulate autophagocytic engulfment, which
                      would facilitate transport of the nanoparticles into
                      lysosomes and would lead to subsequent degradation of
                      nanoparticle-attached proteins.},
      cin          = {ICS-2},
      ddc          = {600},
      cid          = {I:(DE-Juel1)ICS-2-20110106},
      pnm          = {552 - Engineering Cell Function (POF3-552)},
      pid          = {G:(DE-HGF)POF3-552},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29565057},
      UT           = {WOS:000429530400025},
      doi          = {10.1039/C7NR08856F},
      url          = {https://juser.fz-juelich.de/record/844894},
}