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000844995 1001_ $$0P:(DE-Juel1)169139$$aKolasinac, Rejhana$$b0
000844995 245__ $$aDeciphering the Functional Composition of Fusogenic Liposomes
000844995 260__ $$aBasel$$bMolecular Diversity Preservation International$$c2018
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000844995 520__ $$aCationic liposomes are frequently used as carrier particles for nucleic acid delivery. The most popular formulation is the equimolar mixture of two components, a cationic lipid and a neutral phosphoethanolamine. Its uptake pathway has been described as endocytosis. The presence of an aromatic molecule as a third component strongly influences the cellular uptake process and results in complete membrane fusion instead of endocytosis. Here, we systematically varied all three components of this lipid mixture and determined how efficiently the resulting particles fused with the plasma membrane of living mammalian cells. Our results show that an aromatic molecule and a cationic lipid component with conical molecular shape are essential for efficient fusion induction. While a neutral lipid is not mandatory, it can be used to control fusion efficiency and, in the most extreme case, to revert the uptake mechanism back to endocytosis
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000844995 7001_ $$0P:(DE-Juel1)139021$$aKleusch, Christian$$b1
000844995 7001_ $$0P:(DE-Juel1)151181$$aBraun, Tobias$$b2
000844995 7001_ $$0P:(DE-Juel1)128833$$aMerkel, Rudolf$$b3
000844995 7001_ $$0P:(DE-Juel1)128805$$aCsiszar, Agnes$$b4$$eCorresponding author
000844995 773__ $$0PERI:(DE-600)2019364-6$$a10.3390/ijms19020346$$gVol. 19, no. 2, p. 346 -$$n2$$p346 -$$tInternational journal of molecular sciences$$v19$$x1422-0067$$y2018
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