TY  - JOUR
AU  - Del Guerra, Alberto
AU  - Ahmad, Salleh
AU  - Avram, Mihai
AU  - Belcari, Nicola
AU  - Berneking, Arne
AU  - Biagi, Laura
AU  - Bisogni, Maria Giuseppina
AU  - Brandl, Felix
AU  - Cabello, Jorge
AU  - Camarlinghi, Niccolò
AU  - Cerello, Piergiorgio
AU  - Choi, Chang-Hoon
AU  - Coli, Silvia
AU  - Colpo, Sabrina
AU  - Fleury, Julien
AU  - Gagliardi, Vito
AU  - Giraudo, Giuseppe
AU  - Heekeren, Karsten
AU  - Kawohl, Wolfram
AU  - Kostou, Theodora
AU  - Lefaucheur, Jean-Luc
AU  - Lerche, Christoph
AU  - Loudos, George
AU  - Morrocchi, Matteo
AU  - Muller, Julien
AU  - Mustafa, Mona
AU  - Neuner, Irene
AU  - Papadimitroulas, Panagiotis
AU  - Pennazio, Francesco
AU  - Rajkumar, Ravichandran
AU  - Brambilla, Cláudia Régio
AU  - Rivoire, Julien
AU  - Rota Kops, Elena
AU  - Scheins, Jürgen
AU  - Schimpf, Rémy
AU  - Shah, N. J.
AU  - Sorg, Christian
AU  - Sportelli, Giancarlo
AU  - Tosetti, Michela
AU  - Trinchero, Riccardo
AU  - Wyss, Christine
AU  - Ziegler, Sibylle
TI  - TRIMAGE: A dedicated trimodality (PET/MR/EEG) imaging tool for schizophrenia
JO  - European psychiatry
VL  - 50
SN  - 0924-9338
CY  - Paris
PB  - Elsevier80025
M1  - FZJ-2018-02448
SP  - 7 - 20
PY  - 2018
AB  - Simultaneous PET/MR/EEG (Positron Emission Tomography – Magnetic Resonance – Electroencephalography), a new tool for the investigation of neuronal networks in the human brain, is presented here within the framework of the European Union Project TRIMAGE. The trimodal, cost-effective PET/MR/EEG imaging tool makes use of cutting edge technology both in PET and in MR fields. A novel type of magnet (1.5T, non-cryogenic) has been built together with a PET scanner that makes use of the most advanced photodetectors (i.e., SiPM matrices), scintillators matrices (LYSO) and digital electronics. The combined PET/MR/EEG system is dedicated to brain imaging and has an inner diameter of 260 mm and an axial Field-of-View of 160 mm.It enables the acquisition and assessment of molecular metabolic information with high spatial and temporal resolution in a given brain simultaneously. The dopaminergic system and the glutamatergic system in schizophrenic patients are investigated via PET, the same physiological/pathophysiological conditions with regard to functional connectivity, via fMRI, and its electrophysiological signature via EEG. In addition to basic neuroscience questions addressing neurovascular-metabolic coupling, this new methodology lays the foundation for individual physiological and pathological fingerprints for a wide research field addressing healthy aging, gender effects, plasticity and different psychiatric and neurological diseases.The preliminary performances of two components of the imaging tool (PET and MR) are discussed. Initial results of the search of possible candidates for suitable schizophrenia biomarkers are also presented as obtained with PET/MR systems available to the collaboration.
LB  - PUB:(DE-HGF)16
C6  - pmid:29358016
UR  - <Go to ISI:>//WOS:000430263900003
DO  - DOI:10.1016/j.eurpsy.2017.11.007
UR  - https://juser.fz-juelich.de/record/845129
ER  -