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@ARTICLE{DelGuerra:845129,
author = {Del Guerra, Alberto and Ahmad, Salleh and Avram, Mihai and
Belcari, Nicola and Berneking, Arne and Biagi, Laura and
Bisogni, Maria Giuseppina and Brandl, Felix and Cabello,
Jorge and Camarlinghi, Niccolò and Cerello, Piergiorgio and
Choi, Chang-Hoon and Coli, Silvia and Colpo, Sabrina and
Fleury, Julien and Gagliardi, Vito and Giraudo, Giuseppe and
Heekeren, Karsten and Kawohl, Wolfram and Kostou, Theodora
and Lefaucheur, Jean-Luc and Lerche, Christoph and Loudos,
George and Morrocchi, Matteo and Muller, Julien and Mustafa,
Mona and Neuner, Irene and Papadimitroulas, Panagiotis and
Pennazio, Francesco and Rajkumar, Ravichandran and
Brambilla, Cláudia Régio and Rivoire, Julien and Rota
Kops, Elena and Scheins, Jürgen and Schimpf, Rémy and
Shah, N. J. and Sorg, Christian and Sportelli, Giancarlo and
Tosetti, Michela and Trinchero, Riccardo and Wyss, Christine
and Ziegler, Sibylle},
title = {{TRIMAGE}: {A} dedicated trimodality ({PET}/{MR}/{EEG})
imaging tool for schizophrenia},
journal = {European psychiatry},
volume = {50},
issn = {0924-9338},
address = {Paris},
publisher = {Elsevier80025},
reportid = {FZJ-2018-02448},
pages = {7 - 20},
year = {2018},
abstract = {Simultaneous PET/MR/EEG (Positron Emission Tomography –
Magnetic Resonance – Electroencephalography), a new tool
for the investigation of neuronal networks in the human
brain, is presented here within the framework of the
European Union Project TRIMAGE. The trimodal, cost-effective
PET/MR/EEG imaging tool makes use of cutting edge technology
both in PET and in MR fields. A novel type of magnet (1.5T,
non-cryogenic) has been built together with a PET scanner
that makes use of the most advanced photodetectors (i.e.,
SiPM matrices), scintillators matrices (LYSO) and digital
electronics. The combined PET/MR/EEG system is dedicated to
brain imaging and has an inner diameter of 260 mm and an
axial Field-of-View of 160 mm.It enables the acquisition
and assessment of molecular metabolic information with high
spatial and temporal resolution in a given brain
simultaneously. The dopaminergic system and the
glutamatergic system in schizophrenic patients are
investigated via PET, the same
physiological/pathophysiological conditions with regard to
functional connectivity, via fMRI, and its
electrophysiological signature via EEG. In addition to basic
neuroscience questions addressing neurovascular-metabolic
coupling, this new methodology lays the foundation for
individual physiological and pathological fingerprints for a
wide research field addressing healthy aging, gender
effects, plasticity and different psychiatric and
neurological diseases.The preliminary performances of two
components of the imaging tool (PET and MR) are discussed.
Initial results of the search of possible candidates for
suitable schizophrenia biomarkers are also presented as
obtained with PET/MR systems available to the
collaboration.},
cin = {INM-4 / JARA-BRAIN},
ddc = {610},
cid = {I:(DE-Juel1)INM-4-20090406 / $I:(DE-82)080010_20140620$},
pnm = {573 - Neuroimaging (POF3-573)},
pid = {G:(DE-HGF)POF3-573},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:29358016},
UT = {WOS:000430263900003},
doi = {10.1016/j.eurpsy.2017.11.007},
url = {https://juser.fz-juelich.de/record/845129},
}