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@ARTICLE{DelGuerra:845129,
      author       = {Del Guerra, Alberto and Ahmad, Salleh and Avram, Mihai and
                      Belcari, Nicola and Berneking, Arne and Biagi, Laura and
                      Bisogni, Maria Giuseppina and Brandl, Felix and Cabello,
                      Jorge and Camarlinghi, Niccolò and Cerello, Piergiorgio and
                      Choi, Chang-Hoon and Coli, Silvia and Colpo, Sabrina and
                      Fleury, Julien and Gagliardi, Vito and Giraudo, Giuseppe and
                      Heekeren, Karsten and Kawohl, Wolfram and Kostou, Theodora
                      and Lefaucheur, Jean-Luc and Lerche, Christoph and Loudos,
                      George and Morrocchi, Matteo and Muller, Julien and Mustafa,
                      Mona and Neuner, Irene and Papadimitroulas, Panagiotis and
                      Pennazio, Francesco and Rajkumar, Ravichandran and
                      Brambilla, Cláudia Régio and Rivoire, Julien and Rota
                      Kops, Elena and Scheins, Jürgen and Schimpf, Rémy and
                      Shah, N. J. and Sorg, Christian and Sportelli, Giancarlo and
                      Tosetti, Michela and Trinchero, Riccardo and Wyss, Christine
                      and Ziegler, Sibylle},
      title        = {{TRIMAGE}: {A} dedicated trimodality ({PET}/{MR}/{EEG})
                      imaging tool for schizophrenia},
      journal      = {European psychiatry},
      volume       = {50},
      issn         = {0924-9338},
      address      = {Paris},
      publisher    = {Elsevier80025},
      reportid     = {FZJ-2018-02448},
      pages        = {7 - 20},
      year         = {2018},
      abstract     = {Simultaneous PET/MR/EEG (Positron Emission Tomography –
                      Magnetic Resonance – Electroencephalography), a new tool
                      for the investigation of neuronal networks in the human
                      brain, is presented here within the framework of the
                      European Union Project TRIMAGE. The trimodal, cost-effective
                      PET/MR/EEG imaging tool makes use of cutting edge technology
                      both in PET and in MR fields. A novel type of magnet (1.5T,
                      non-cryogenic) has been built together with a PET scanner
                      that makes use of the most advanced photodetectors (i.e.,
                      SiPM matrices), scintillators matrices (LYSO) and digital
                      electronics. The combined PET/MR/EEG system is dedicated to
                      brain imaging and has an inner diameter of 260 mm and an
                      axial Field-of-View of 160 mm.It enables the acquisition
                      and assessment of molecular metabolic information with high
                      spatial and temporal resolution in a given brain
                      simultaneously. The dopaminergic system and the
                      glutamatergic system in schizophrenic patients are
                      investigated via PET, the same
                      physiological/pathophysiological conditions with regard to
                      functional connectivity, via fMRI, and its
                      electrophysiological signature via EEG. In addition to basic
                      neuroscience questions addressing neurovascular-metabolic
                      coupling, this new methodology lays the foundation for
                      individual physiological and pathological fingerprints for a
                      wide research field addressing healthy aging, gender
                      effects, plasticity and different psychiatric and
                      neurological diseases.The preliminary performances of two
                      components of the imaging tool (PET and MR) are discussed.
                      Initial results of the search of possible candidates for
                      suitable schizophrenia biomarkers are also presented as
                      obtained with PET/MR systems available to the
                      collaboration.},
      cin          = {INM-4 / JARA-BRAIN},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-4-20090406 / $I:(DE-82)080010_20140620$},
      pnm          = {573 - Neuroimaging (POF3-573)},
      pid          = {G:(DE-HGF)POF3-573},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29358016},
      UT           = {WOS:000430263900003},
      doi          = {10.1016/j.eurpsy.2017.11.007},
      url          = {https://juser.fz-juelich.de/record/845129},
}