TY  - JOUR
AU  - Patronis, Alexander
AU  - Richardson, Robin A.
AU  - Schmieschek, Sebastian
AU  - Wylie, Brian J. N.
AU  - Nash, Rupert W.
AU  - Coveney, Peter V.
TI  - Modeling Patient-Specific Magnetic Drug Targeting Within the Intracranial Vasculature
JO  - Frontiers in physiology
VL  - 9
SN  - 1664-042X
CY  - Lausanne
PB  - Frontiers Research Foundation
M1  - FZJ-2018-02669
SP  - 331
PY  - 2018
AB  - Drug targeting promises to substantially enhance future therapies, for example through the focussing of chemotherapeutic drugs at the site of a tumor, thus reducing the exposure of healthy tissue to unwanted damage. Promising work on the steering of medication in the human body employs magnetic fields acting on nanoparticles made of paramagnetic materials. We develop a computational tool to aid in the optimization of the physical parameters of these particles and the magnetic configuration, estimating the fraction of particles reaching a given target site in a large patient-specific vascular system for different physiological states (heart rate, cardiac output, etc.). We demonstrate the excellent computational performance of our model by its application to the simulation of paramagnetic-nanoparticle-laden flows in a circle of Willis geometry obtained from an MRI scan. The results suggest a strong dependence of the particle density at the target site on the strength of the magnetic forcing and the velocity of the background fluid flow.
LB  - PUB:(DE-HGF)16
C6  - pmid:29725303
UR  - <Go to ISI:>//WOS:000430429900001
DO  - DOI:10.3389/fphys.2018.00331
UR  - https://juser.fz-juelich.de/record/845398
ER  -