% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Patronis:845398,
      author       = {Patronis, Alexander and Richardson, Robin A. and
                      Schmieschek, Sebastian and Wylie, Brian J. N. and Nash,
                      Rupert W. and Coveney, Peter V.},
      title        = {{M}odeling {P}atient-{S}pecific {M}agnetic {D}rug
                      {T}argeting {W}ithin the {I}ntracranial {V}asculature},
      journal      = {Frontiers in physiology},
      volume       = {9},
      issn         = {1664-042X},
      address      = {Lausanne},
      publisher    = {Frontiers Research Foundation},
      reportid     = {FZJ-2018-02669},
      pages        = {331},
      year         = {2018},
      abstract     = {Drug targeting promises to substantially enhance future
                      therapies, for example through the focussing of
                      chemotherapeutic drugs at the site of a tumor, thus reducing
                      the exposure of healthy tissue to unwanted damage. Promising
                      work on the steering of medication in the human body employs
                      magnetic fields acting on nanoparticles made of paramagnetic
                      materials. We develop a computational tool to aid in the
                      optimization of the physical parameters of these particles
                      and the magnetic configuration, estimating the fraction of
                      particles reaching a given target site in a large
                      patient-specific vascular system for different physiological
                      states (heart rate, cardiac output, etc.). We demonstrate
                      the excellent computational performance of our model by its
                      application to the simulation of
                      paramagnetic-nanoparticle-laden flows in a circle of Willis
                      geometry obtained from an MRI scan. The results suggest a
                      strong dependence of the particle density at the target site
                      on the strength of the magnetic forcing and the velocity of
                      the background fluid flow.},
      cin          = {JSC},
      ddc          = {610},
      cid          = {I:(DE-Juel1)JSC-20090406},
      pnm          = {511 - Computational Science and Mathematical Methods
                      (POF3-511) / CompBioMed - A Centre of Excellence in
                      Computational Biomedicine (675451) / POP - Performance
                      Optimisation and Productivity (676553) / ATMLPP - ATML
                      Parallel Performance (ATMLPP)},
      pid          = {G:(DE-HGF)POF3-511 / G:(EU-Grant)675451 /
                      G:(EU-Grant)676553 / G:(DE-Juel-1)ATMLPP},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29725303},
      UT           = {WOS:000430429900001},
      doi          = {10.3389/fphys.2018.00331},
      url          = {https://juser.fz-juelich.de/record/845398},
}