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@ARTICLE{Kleineberg:845433,
      author       = {Kleineberg, Nina and Dovern, Anna and Binder, Ellen and
                      Grefkes, Christian and Eickhoff, Simon and Fink, Gereon R.
                      and Weiss, Peter H.},
      title        = {{A}ction and semantic tool knowledge - {E}ffective
                      connectivity in the underlying neural networks},
      journal      = {Human brain mapping},
      volume       = {39},
      number       = {9},
      issn         = {1065-9471},
      address      = {New York, NY},
      publisher    = {Wiley-Liss},
      reportid     = {FZJ-2018-02697},
      pages        = {3473-3486},
      year         = {2018},
      note         = {Funding information Medical Faculty, University of Cologne,
                      Grant/Award Number: 3615/0129/31; Marga‐ and Walter‐Boll
                      Stiftung; Helmholtz Portfolio Theme “Supercomputing and
                      Modeling for the Human Brain”; University of Cologne
                      Emerging Groups Initiative (CONNECT group) implemented into
                      the Institutional Strategy of the University of Cologne and
                      the German Excellence Initiative},
      abstract     = {Evidence from neuropsychological and imaging studies
                      indicate that action and semantic knowledge about tools draw
                      upon distinct neural substrates, but little is known about
                      the underlying interregional effective connectivity. With
                      fMRI and dynamic causal modeling (DCM) we investigated
                      effective connectivity in the left‐hemisphere (LH) while
                      subjects performed (i) a function knowledge and (ii) a value
                      knowledge task, both addressing semantic tool knowledge, and
                      (iii) a manipulation (action) knowledge task. Overall, the
                      results indicate crosstalk between action nodes and semantic
                      nodes. Interestingly, effective connectivity was weakened
                      between semantic nodes and action nodes during the
                      manipulation task. Furthermore, pronounced modulations of
                      effective connectivity within the fronto‐parietal action
                      system of the LH (comprising lateral occipito‐temporal
                      cortex, intraparietal sulcus, supramarginal gyrus, inferior
                      frontal gyrus) were observed in a bidirectional manner
                      during the processing of action knowledge. In contrast, the
                      function and value knowledge tasks resulted in a significant
                      strengthening of the effective connectivity between visual
                      cortex and fusiform gyrus. Importantly, this modulation was
                      present in both semantic tasks, indicating that processing
                      different aspects of semantic knowledge about tools evokes
                      similar effective connectivity patterns. Data revealed that
                      interregional effective connectivity during the processing
                      of tool knowledge occurred in a bidirectional manner with a
                      weakening of connectivity between areas engaged in action
                      and semantic knowledge about tools during the processing of
                      action knowledge. Moreover, different semantic tool
                      knowledge tasks elicited similar effective connectivity
                      patterns.},
      cin          = {INM-7 / INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406 / I:(DE-Juel1)INM-3-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29700893},
      UT           = {WOS:000441276600001},
      doi          = {10.1002/hbm.24188},
      url          = {https://juser.fz-juelich.de/record/845433},
}