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@ARTICLE{Verger:845506,
      author       = {Verger, Antoine and Stoffels, Gabriele and Galldiks,
                      Norbert and Lohmann, Philipp and Willuweit, Antje and
                      Neumaier, Bernd and Geisler, Stefanie and Langen,
                      Karl-Josef},
      title        = {{I}nvestigation of cis-4-[18{F}]{F}luoro-{D}-{P}roline
                      {U}ptake in {H}uman {B}rain {T}umors {A}fter {M}ultimodal
                      {T}reatment},
      journal      = {Molecular imaging $\&$ biology},
      volume       = {20},
      number       = {6},
      issn         = {1860-2002},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2018-02740},
      pages        = {1035–1043},
      year         = {2018},
      abstract     = {PurposeCis-4-[18F]fluoro-D-proline (D-cis-[18F]FPro) has
                      been shown to pass the intact blood-brain barrier and to
                      accumulate in areas of secondary neurodegeneration and
                      necrosis in the rat brain while uptake in experimental brain
                      tumors is low. This pilot study explores the uptake behavior
                      of D-cis-[18F]FPro in human brain tumors after multimodal
                      treatment.ProceduresIn a prospective study, 27 patients with
                      suspected recurrent brain tumor after treatment with
                      surgery, radiotherapy, and/or chemotherapy (SRC) were
                      investigated by dynamic positron emission tomography (PET)
                      using D-cis-[18F]FPro (22 high-grade gliomas, one
                      unspecified glioma, and 4 metastases). Furthermore, two
                      patients with untreated lesions were included (one
                      glioblastoma, one reactive astrogliosis). Data were compared
                      with the results of PET using
                      O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET) which detects
                      viable tumor tissue. Tracer distribution, mean and maximum
                      lesion-to-brain ratios (LBRmean, LBRmax), and time-to-peak
                      (TTP) of the time activity curve (TAC) of tracer uptake were
                      evaluated. Final diagnosis was determined by histology
                      (n = 9), clinical follow-up (n = 10), or by [18F]FET
                      PET (n = 10).ResultsD-cis-[18F]FPro showed high uptake
                      in both recurrent brain tumors (n = 11) and lesions
                      classified as treatment-related changes (TRC) only
                      (n = 16) (LBRmean 2.2 ± 0.7 and 2.1 ± 0.6,
                      n.s.; LBRmax 3.4 ± 1.2 and 3.2 ± 1.3, n.s.). The
                      untreated glioblastoma and the lesion showing reactive
                      astrogliosis exhibited low D-cis-[18F]FPro uptake.
                      Distribution of [18F]FET and D-cis-[18F]FPro uptake was
                      discordant in 21/29 cases indicating that the uptake
                      mechanisms are different.ConclusionThe high accumulation of
                      D-cis-[18F]FPro in pretreated brain tumors and TRC supports
                      the hypothesis that tracer uptake is related to cell death.
                      Further studies before and after therapy are needed to
                      assess the potential of D-cis-[18F]FPro for treatment
                      monitoring.},
      cin          = {INM-3 / INM-4 / INM-5},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406 / I:(DE-Juel1)INM-4-20090406 /
                      I:(DE-Juel1)INM-5-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29687323},
      UT           = {WOS:000450173100016},
      doi          = {10.1007/s11307-018-1197-8},
      url          = {https://juser.fz-juelich.de/record/845506},
}