%0 Journal Article
%A Graham, Ben
%A Fayter, Alice E. R.
%A Houston, Judith E.
%A Evans, Rachel C.
%A Gibson, Matthew I.
%T Facially Amphipathic Glycopolymers Inhibit Ice Recrystallization
%J Journal of the American Chemical Society
%V 140
%N 17
%@ 1520-5126
%C Washington, DC
%I American Chemical Society
%M FZJ-2018-02760
%P 5682 - 5685
%D 2018
%X Antifreeze glycoproteins (AFGPs) from polar fish are the most potent ice recrystallization (growth) inhibitors known, and synthetic mimics are required for low-temperature applications such as cell cryopreservation. Here we introduce facially amphipathic glycopolymers that mimic the three-dimensional structure of AFGPs. Glycopolymers featuring segregated hydrophilic and hydrophobic faces were prepared by ring-opening metathesis polymerization, and their rigid conformation was confirmed by small-angle neutron scattering. Ice recrystallization inhibition (IRI) activity was reduced when a hydrophilic oxo-ether was installed on the glycan-opposing face, but significant activity was restored by incorporating a hydrophobic dimethylfulvene residue. This biomimetic strategy demonstrates that segregated domains of distinct hydrophilicity/hydrophobicity are a crucial motif to introduce IRI activity, which increases our understanding of the complex ice crystal inhibition processes.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:29660982
%U <Go to ISI:>//WOS:000431600000006
%R 10.1021/jacs.8b02066
%U https://juser.fz-juelich.de/record/845526