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000845526 1001_ $$00000-0003-1313-6874$$aGraham, Ben$$b0
000845526 245__ $$aFacially Amphipathic Glycopolymers Inhibit Ice Recrystallization
000845526 260__ $$aWashington, DC$$bAmerican Chemical Society$$c2018
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000845526 520__ $$aAntifreeze glycoproteins (AFGPs) from polar fish are the most potent ice recrystallization (growth) inhibitors known, and synthetic mimics are required for low-temperature applications such as cell cryopreservation. Here we introduce facially amphipathic glycopolymers that mimic the three-dimensional structure of AFGPs. Glycopolymers featuring segregated hydrophilic and hydrophobic faces were prepared by ring-opening metathesis polymerization, and their rigid conformation was confirmed by small-angle neutron scattering. Ice recrystallization inhibition (IRI) activity was reduced when a hydrophilic oxo-ether was installed on the glycan-opposing face, but significant activity was restored by incorporating a hydrophobic dimethylfulvene residue. This biomimetic strategy demonstrates that segregated domains of distinct hydrophilicity/hydrophobicity are a crucial motif to introduce IRI activity, which increases our understanding of the complex ice crystal inhibition processes.
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000845526 7001_ $$00000-0001-9470-9560$$aFayter, Alice E. R.$$b1
000845526 7001_ $$0P:(DE-Juel1)171614$$aHouston, Judith E.$$b2
000845526 7001_ $$00000-0003-2956-4857$$aEvans, Rachel C.$$b3
000845526 7001_ $$00000-0002-8297-1278$$aGibson, Matthew I.$$b4$$eCorresponding author
000845526 773__ $$0PERI:(DE-600)1472210-0$$a10.1021/jacs.8b02066$$gVol. 140, no. 17, p. 5682 - 5685$$n17$$p5682 - 5685$$tJournal of the American Chemical Society$$v140$$x1520-5126$$y2018
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