TY  - JOUR
AU  - Graham, Ben
AU  - Fayter, Alice E. R.
AU  - Houston, Judith E.
AU  - Evans, Rachel C.
AU  - Gibson, Matthew I.
TI  - Facially Amphipathic Glycopolymers Inhibit Ice Recrystallization
JO  - Journal of the American Chemical Society
VL  - 140
IS  - 17
SN  - 1520-5126
CY  - Washington, DC
PB  - American Chemical Society
M1  - FZJ-2018-02760
SP  - 5682 - 5685
PY  - 2018
AB  - Antifreeze glycoproteins (AFGPs) from polar fish are the most potent ice recrystallization (growth) inhibitors known, and synthetic mimics are required for low-temperature applications such as cell cryopreservation. Here we introduce facially amphipathic glycopolymers that mimic the three-dimensional structure of AFGPs. Glycopolymers featuring segregated hydrophilic and hydrophobic faces were prepared by ring-opening metathesis polymerization, and their rigid conformation was confirmed by small-angle neutron scattering. Ice recrystallization inhibition (IRI) activity was reduced when a hydrophilic oxo-ether was installed on the glycan-opposing face, but significant activity was restored by incorporating a hydrophobic dimethylfulvene residue. This biomimetic strategy demonstrates that segregated domains of distinct hydrophilicity/hydrophobicity are a crucial motif to introduce IRI activity, which increases our understanding of the complex ice crystal inhibition processes.
LB  - PUB:(DE-HGF)16
C6  - pmid:29660982
UR  - <Go to ISI:>//WOS:000431600000006
DO  - DOI:10.1021/jacs.8b02066
UR  - https://juser.fz-juelich.de/record/845526
ER  -