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@ARTICLE{Graham:845526,
      author       = {Graham, Ben and Fayter, Alice E. R. and Houston, Judith E.
                      and Evans, Rachel C. and Gibson, Matthew I.},
      title        = {{F}acially {A}mphipathic {G}lycopolymers {I}nhibit {I}ce
                      {R}ecrystallization},
      journal      = {Journal of the American Chemical Society},
      volume       = {140},
      number       = {17},
      issn         = {1520-5126},
      address      = {Washington, DC},
      publisher    = {American Chemical Society},
      reportid     = {FZJ-2018-02760},
      pages        = {5682 - 5685},
      year         = {2018},
      abstract     = {Antifreeze glycoproteins (AFGPs) from polar fish are the
                      most potent ice recrystallization (growth) inhibitors known,
                      and synthetic mimics are required for low-temperature
                      applications such as cell cryopreservation. Here we
                      introduce facially amphipathic glycopolymers that mimic the
                      three-dimensional structure of AFGPs. Glycopolymers
                      featuring segregated hydrophilic and hydrophobic faces were
                      prepared by ring-opening metathesis polymerization, and
                      their rigid conformation was confirmed by small-angle
                      neutron scattering. Ice recrystallization inhibition (IRI)
                      activity was reduced when a hydrophilic oxo-ether was
                      installed on the glycan-opposing face, but significant
                      activity was restored by incorporating a hydrophobic
                      dimethylfulvene residue. This biomimetic strategy
                      demonstrates that segregated domains of distinct
                      hydrophilicity/hydrophobicity are a crucial motif to
                      introduce IRI activity, which increases our understanding of
                      the complex ice crystal inhibition processes.},
      cin          = {JCNS-FRM-II / Neutronenstreuung ; JCNS-1},
      ddc          = {540},
      cid          = {I:(DE-Juel1)JCNS-FRM-II-20110218 /
                      I:(DE-Juel1)JCNS-1-20110106},
      pnm          = {6G15 - FRM II / MLZ (POF3-6G15) / 6G4 - Jülich Centre for
                      Neutron Research (JCNS) (POF3-623)},
      pid          = {G:(DE-HGF)POF3-6G15 / G:(DE-HGF)POF3-6G4},
      experiment   = {EXP:(DE-MLZ)KWS2-20140101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29660982},
      UT           = {WOS:000431600000006},
      doi          = {10.1021/jacs.8b02066},
      url          = {https://juser.fz-juelich.de/record/845526},
}