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005     20210129233453.0
024 7 _ |a 10.1021/jacs.8b02066
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100 1 _ |a Graham, Ben
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245 _ _ |a Facially Amphipathic Glycopolymers Inhibit Ice Recrystallization
260 _ _ |a Washington, DC
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520 _ _ |a Antifreeze glycoproteins (AFGPs) from polar fish are the most potent ice recrystallization (growth) inhibitors known, and synthetic mimics are required for low-temperature applications such as cell cryopreservation. Here we introduce facially amphipathic glycopolymers that mimic the three-dimensional structure of AFGPs. Glycopolymers featuring segregated hydrophilic and hydrophobic faces were prepared by ring-opening metathesis polymerization, and their rigid conformation was confirmed by small-angle neutron scattering. Ice recrystallization inhibition (IRI) activity was reduced when a hydrophilic oxo-ether was installed on the glycan-opposing face, but significant activity was restored by incorporating a hydrophobic dimethylfulvene residue. This biomimetic strategy demonstrates that segregated domains of distinct hydrophilicity/hydrophobicity are a crucial motif to introduce IRI activity, which increases our understanding of the complex ice crystal inhibition processes.
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700 1 _ |a Fayter, Alice E. R.
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700 1 _ |a Houston, Judith E.
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700 1 _ |a Evans, Rachel C.
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700 1 _ |a Gibson, Matthew I.
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773 _ _ |a 10.1021/jacs.8b02066
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