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@ARTICLE{Yu:845572,
      author       = {Yu, Shun and Kent, Ben and Jafta, Charl J. and Petzold,
                      Albrecht and Radulescu, Aurel and Schuchardt, Mirjam and
                      Tölle, Markus and van der Giet, Markus and Zidek, Walter
                      and Ballauff, Matthias},
      title        = {{S}tability of human serum albumin structure upon toxin
                      uptake explored by small angle neutron scattering},
      journal      = {Polymer},
      volume       = {141},
      issn         = {0032-3861},
      address      = {Oxford},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2018-02797},
      pages        = {175 - 183},
      year         = {2018},
      abstract     = {Possible denaturation or tertiary structural changes of the
                      protein human serum albumin (HSA) upon adsorption of uremic
                      toxin is investigated using small-angle neutron scattering
                      (SANS). Calorimetric data in previous studies give proof of
                      the binding between HSA and two classes of uremic toxins: i)
                      small molecular weight and ii) middle molecular weight
                      molecules. A representative polyelectrolyte of negative net
                      charge is used as a model middle molecule and two molecules
                      phenylacetic acid (PhAA) and indoxyl sulfate (IDS) represent
                      the small molecular weight toxins. The present study find no
                      proof of destabilization of the protein structure upon toxin
                      uptake. Analyzing the structure factor of scattering
                      intensities from high concentrated protein samples complexed
                      with PhAA and IDS show that interaction between native and
                      complexed HSA is also not altered. However, a small effect
                      of the net charge of HSA is found in the case of urea
                      modified proteins},
      cin          = {JCNS-FRM-II / Neutronenstreuung ; JCNS-1},
      ddc          = {540},
      cid          = {I:(DE-Juel1)JCNS-FRM-II-20110218 /
                      I:(DE-Juel1)JCNS-1-20110106},
      pnm          = {6G15 - FRM II / MLZ (POF3-6G15) / 6G4 - Jülich Centre for
                      Neutron Research (JCNS) (POF3-623)},
      pid          = {G:(DE-HGF)POF3-6G15 / G:(DE-HGF)POF3-6G4},
      experiment   = {EXP:(DE-MLZ)KWS2-20140101},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000429484400019},
      doi          = {10.1016/j.polymer.2018.02.060},
      url          = {https://juser.fz-juelich.de/record/845572},
}