TY  - JOUR
AU  - Kipping, Judy A.
AU  - Margulies, Daniel S.
AU  - Eickhoff, Simon
AU  - Lee, Annie
AU  - Qiu, Anqi
TI  - Trade-off of cerebello-cortical and cortico-cortical functional networks for planning in 6-year-old children
JO  - NeuroImage
VL  - 176
SN  - 1053-8119
CY  - Orlando, Fla.
PB  - Academic Press
M1  - FZJ-2018-02927
SP  - 510-517
PY  - 2018
AB  - Childhood is a critical period for the development of cognitive planning. There is a lack of knowledge on its neural mechanisms in children. This study aimed to examine cerebello-cortical and cortico-cortical functional connectivity in association with planning skills in 6-year-olds (n = 76). We identified the cerebello-cortical and cortico-cortical functional networks related to cognitive planning using activation likelihood estimation (ALE) meta-analysis on existing functional imaging studies on spatial planning, and data-driven independent component analysis (ICA) of children's resting-state functional MRI (rs-fMRI). We investigated associations of cerebello-cortical and cortico-cortical functional connectivity with planning ability in 6-year-olds, as assessed using the Stockings of Cambridge task. Long-range functional connectivity of two cerebellar networks (lobules VI and lateral VIIa) with the prefrontal and premotor cortex were greater in children with poorer planning ability. In contrast, cortico-cortical association networks were not associated with the performance of planning in children. These results highlighted the key contribution of the lateral cerebello-frontal functional connectivity, but not cortico-cortical association functional connectivity, for planning ability in 6-year-olds. Our results suggested that brain adaptation to the acquisition of planning ability during childhood is partially achieved through the engagement of the cerebello-cortical functional connectivity.
LB  - PUB:(DE-HGF)16
C6  - pmid:29730492
UR  - <Go to ISI:>//WOS:000433223700043
DO  - DOI:10.1016/j.neuroimage.2018.04.067
UR  - https://juser.fz-juelich.de/record/845715
ER  -