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@ARTICLE{Wray:845891,
author = {Wray, Naomi R. and Ripke, Stephan and Mattheisen, Manuel
and Trzaskowski, Maciej and Byrne, Enda M. and Abdellaoui,
Abdel and Adams, Mark J. and Agerbo, Esben and Air, Tracy M.
and Andlauer, Till M. F. and Bacanu, Silviu-Alin and
Bækvad-Hansen, Marie and Beekman, Aartjan F. T. and
Bigdeli, Tim B. and Binder, Elisabeth B. and Blackwood,
Douglas R. H. and Bryois, Julien and Buttenschøn, Henriette
N. and Bybjerg-Grauholm, Jonas and Cai, Na and Castelao,
Enrique and Christensen, Jane Hvarregaard and Clarke,
Toni-Kim and Coleman, Jonathan I. R. and Colodro-Conde,
Lucía and Couvy-Duchesne, Baptiste and Craddock, Nick and
Crawford, Gregory E. and Crowley, Cheynna A. and Dashti,
Hassan S. and Davies, Gail and Deary, Ian J. and Degenhardt,
Franziska and Derks, Eske M. and Direk, Nese and Dolan,
Conor V. and Dunn, Erin C. and Eley, Thalia C. and Eriksson,
Nicholas and Escott-Price, Valentina and Kiadeh, Farnush
Hassan Farhadi and Finucane, Hilary K. and Forstner, Andreas
J. and Frank, Josef and Gaspar, Héléna A. and Gill,
Michael and Giusti-Rodríguez, Paola and Goes, Fernando S.
and Gordon, Scott D. and Grove, Jakob and Hall, Lynsey S.
and Hannon, Eilis and Hansen, Christine Søholm and Hansen,
Thomas F. and Herms, Stefan and Hickie, Ian B. and Hoffmann,
Per and Homuth, Georg and Horn, Carsten and Hottenga,
Jouke-Jan and Hougaard, David M. and Hu, Ming and Hyde,
Craig L. and Ising, Marcus and Jansen, Rick and Jin, Fulai
and Jorgenson, Eric and Knowles, James A. and Kohane, Isaac
S. and Kraft, Julia and Kretzschmar, Warren W. and Krogh,
Jesper and Kutalik, Zoltán and Lane, Jacqueline M. and Li,
Yihan and Li, Yun and Lind, Penelope A. and Liu, Xiaoxiao
and Lu, Leina and MacIntyre, Donald J. and MacKinnon, Dean
F. and Maier, Robert M. and Maier, Wolfgang and Marchini,
Jonathan and Mbarek, Hamdi and McGrath, Patrick and
McGuffin, Peter and Medland, Sarah E. and Mehta, Divya and
Middeldorp, Christel M. and Mihailov, Evelin and Milaneschi,
Yuri and Milani, Lili and Mill, Jonathan and Mondimore,
Francis M. and Montgomery, Grant W. and Mostafavi, Sara and
Mullins, Niamh and Nauck, Matthias and Ng, Bernard and
Nivard, Michel G. and Nyholt, Dale R. and O’Reilly, Paul
F. and Oskarsson, Hogni and Owen, Michael J. and Painter,
Jodie N. and Pedersen, Carsten Bøcker and Pedersen,
Marianne Giørtz and Peterson, Roseann E. and Pettersson,
Erik and Peyrot, Wouter J. and Pistis, Giorgio and Posthuma,
Danielle and Purcell, Shaun M. and Quiroz, Jorge A. and
Qvist, Per and Rice, John P. and Riley, Brien P. and Rivera,
Margarita and Saeed Mirza, Saira and Saxena, Richa and
Schoevers, Robert and Schulte, Eva C. and Shen, Ling and
Shi, Jianxin and Shyn, Stanley I. and Sigurdsson, Engilbert
and Sinnamon, Grant B. C. and Smit, Johannes H. and Smith,
Daniel J. and Stefansson, Hreinn and Steinberg, Stacy and
Stockmeier, Craig A. and Streit, Fabian and Strohmaier, Jana
and Tansey, Katherine E. and Teismann, Henning and Teumer,
Alexander and Thompson, Wesley and Thomson, Pippa A. and
Thorgeirsson, Thorgeir E. and Tian, Chao and Traylor,
Matthew and Treutlein, Jens and Trubetskoy, Vassily and
Uitterlinden, André G. and Umbricht, Daniel and Van der
Auwera, Sandra and van Hemert, Albert M. and Viktorin,
Alexander and Visscher, Peter M. and Wang, Yunpeng and Webb,
Bradley T. and Weinsheimer, Shantel Marie and Wellmann,
Jürgen and Willemsen, Gonneke and Witt, Stephanie H. and
Wu, Yang and Xi, Hualin S. and Yang, Jian and Zhang, Futao
and Arolt, Volker and Baune, Bernhard T. and Berger, Klaus
and Boomsma, Dorret I. and Cichon, Sven and Dannlowski, Udo
and de Geus, E. C. J. and DePaulo, J. Raymond and Domenici,
Enrico and Domschke, Katharina and Esko, Tõnu and Grabe,
Hans J. and Hamilton, Steven P. and Hayward, Caroline and
Heath, Andrew C. and Hinds, David A. and Kendler, Kenneth S.
and Kloiber, Stefan and Lewis, Glyn and Li, Qingqin S. and
Lucae, Susanne and Madden, Pamela F. A. and Magnusson,
Patrik K. and Martin, Nicholas G. and McIntosh, Andrew M.
and Metspalu, Andres and Mors, Ole and Mortensen, Preben Bo
and Müller-Myhsok, Bertram and Nordentoft, Merete and
Nöthen, Markus M. and O’Donovan, Michael C. and Paciga,
Sara A. and Pedersen, Nancy L. and Penninx, Brenda W. J. H.
and Perlis, Roy H. and Porteous, David J. and Potash, James
B. and Preisig, Martin and Rietschel, Marcella and Schaefer,
Catherine and Schulze, Thomas G. and Smoller, Jordan W. and
Stefansson, Kari and Tiemeier, Henning and Uher, Rudolf and
Völzke, Henry and Weissman, Myrna M. and Werge, Thomas and
Winslow, Ashley R. and Lewis, Cathryn M. and Levinson,
Douglas F. and Breen, Gerome and Børglum, Anders D. and
Sullivan, Patrick F.},
title = {{G}enome-wide association analyses identify 44 risk
variants and refine the genetic architecture of major
depression},
journal = {Nature genetics},
volume = {50},
number = {5},
issn = {1546-1718},
address = {New York, NY},
publisher = {Nature America},
reportid = {FZJ-2018-03090},
pages = {668 - 681},
year = {2018},
abstract = {Major depressive disorder (MDD) is a common illness
accompanied by considerable morbidity, mortality, costs, and
heightened risk of suicide. We conducted a genome-wide
association meta-analysis based in 135,458 cases and 344,901
controls and identified 44 independent and significant loci.
The genetic findings were associated with clinical features
of major depression and implicated brain regions exhibiting
anatomical differences in cases. Targets of antidepressant
medications and genes involved in gene splicing were
enriched for smaller association signal. We found important
relationships of genetic risk for major depression with
educational attainment, body mass, and schizophrenia: lower
educational attainment and higher body mass were putatively
causal, whereas major depression and schizophrenia reflected
a partly shared biological etiology. All humans carry lesser
or greater numbers of genetic risk factors for major
depression. These findings help refine the basis of major
depression and imply that a continuous measure of risk
underlies the clinical phenotype.},
cin = {INM-1},
ddc = {570},
cid = {I:(DE-Juel1)INM-1-20090406},
pnm = {571 - Connectivity and Activity (POF3-571)},
pid = {G:(DE-HGF)POF3-571},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:29700475},
UT = {WOS:000431394900010},
doi = {10.1038/s41588-018-0090-3},
url = {https://juser.fz-juelich.de/record/845891},
}
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