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@ARTICLE{Matei:846015,
      author       = {Matei, Alexandra and Ernst, Corinna and Günl, Markus and
                      Thiele, Björn and Altmüller, Janine and Walbot, Virginia
                      and Usadel, Björn and Doehlemann, Gunther},
      title        = {{H}ow to make a tumour: cell type specific dissection of
                      {U}stilago maydis- induced tumour development in maize
                      leaves},
      journal      = {The new phytologist},
      volume       = {217},
      number       = {4},
      issn         = {0028-646X},
      address      = {Oxford [u.a.]},
      publisher    = {Wiley-Blackwell},
      reportid     = {FZJ-2018-03185},
      pages        = {1681 - 1695},
      year         = {2018},
      abstract     = {The biotrophic fungus Ustilago maydis causes smut disease
                      on maize (Zea mays), which is characterized by immense plant
                      tumours. To establish disease and reprogram organ primordia
                      to tumours, U. maydis deploys effector proteins in an
                      organ‐specific manner. However, the cellular contribution
                      to leaf tumours remains unknown. We investigated leaf tumour
                      formation at the tissue‐ and cell type‐specific levels.
                      Cytology and metabolite analysis were deployed to understand
                      the cellular basis for tumourigenesis. Laser‐capture
                      microdissection was performed to gain a cell type‐specific
                      transcriptome of U. maydis during tumour formation. In vivo
                      visualization of plant DNA synthesis identified bundle
                      sheath cells as the origin of hyperplasic tumour cells,
                      while mesophyll cells become hypertrophic tumour cells. Cell
                      type‐specific transcriptome profiling of U. maydis
                      revealed tailored expression of fungal effector genes.
                      Moreover, U. maydis See1 was identified as the first cell
                      type‐specific fungal effector, being required for
                      induction of cell cycle reactivation in bundle sheath cells.
                      Identification of distinct cellular mechanisms in two
                      different leaf cell types and of See1 as an effector for
                      induction of proliferation of bundle sheath cells are major
                      steps in understanding U. maydis‐induced tumour formation.
                      Moreover, the cell type‐specific U. maydis transcriptome
                      data are a valuable resource to the scientific community.},
      cin          = {IBG-2},
      ddc          = {580},
      cid          = {I:(DE-Juel1)IBG-2-20101118},
      pnm          = {582 - Plant Science (POF3-582)},
      pid          = {G:(DE-HGF)POF3-582},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29314018},
      UT           = {WOS:000424284400026},
      doi          = {10.1111/nph.14960},
      url          = {https://juser.fz-juelich.de/record/846015},
}