000847050 001__ 847050
000847050 005__ 20230207130513.0
000847050 0247_ $$2CORDIS$$aG:(EU-Grant)796778$$d796778
000847050 0247_ $$2CORDIS$$aG:(EU-Call)H2020-MSCA-IF-2017$$dH2020-MSCA-IF-2017
000847050 0247_ $$2originalID$$acorda__h2020::796778
000847050 035__ $$aG:(EU-Grant)796778
000847050 150__ $$aComparative genomics of host-symbiont dependency$$y2018-09-01 - 2020-08-31
000847050 371__ $$aUniversity of London - Queen Mary University of London$$bQMUL$$dUnited Kingdom$$ehttp://www.qmul.ac.uk/$$vCORDIS
000847050 372__ $$aH2020-MSCA-IF-2017$$s2018-09-01$$t2020-08-31
000847050 450__ $$aSYMOBLIGA$$wd$$y2018-09-01 - 2020-08-31
000847050 5101_ $$0I:(DE-588b)5098525-5$$2CORDIS$$aEuropean Union
000847050 680__ $$aOrganisms across the tree of life form partnerships with microbes for protection, metabolic and nutritional benefits. Symbiont acquisitions have allowed hosts to colonise ecological niches that they would otherwise be excluded from, use previously inaccessible resources and capture novel forms of energy. In some cases, host and symbiont become so tightly associated that dependency evolves and the two organisms integrate both physically and genomically. Understanding how organisms combine to perform new metabolic functions and capabilities is key to understanding the evolution of biological complexity. However, most permanent symbioses are ancient and independent evolutionary events, making it difficult to gain information about how dependency evolves. The symbiont Serratia symbiotica has relatively recently transitioned to an essential nutritional role in at least one subfamily of aphids. We provide evidence that dependency on Serratia’s has evolved not once, but several times independently in different aphid lineages. This provides a unique opportunity to explore how symbionts integrate with hosts both genomically and physiologically during the early stages of evolving dependency. We will use a state-of-the-art cross-species comparative genomic analysis in combinations with molecular cytogenetic experiments to determine whether dependency on Serratia has evolved through the same or different genetic mechanisms in the different aphid lineages. First, we will establish a timeline of when each aphid lineage evolved dependency on Serratia. Second, we will identify symbiont genomic rearrangements, the timing of losses and integration of host and symbiont metabolic pathways. Third, we will determine how physical integration evolves. Our findings will provide important information on how microbes and hosts evolve shared metabolic pathways and whether dependency evolves through parallel or convergent processes.
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000847050 970__ $$aoai:dnet:corda__h2020::38eb04aeb48bb8490116d91760b13832
000847050 980__ $$aG
000847050 980__ $$aCORDIS
000847050 980__ $$aAUTHORITY