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@ARTICLE{Chechko:847915,
      author       = {Chechko, Natalia and Cieslik, Edna and Müller, Veronika
                      and Nickl-Jockschat, Thomas and Derntl, Birgit and Kogler,
                      Lydia and Aleman, André and Jardri, Renaud and Sommer, Iris
                      E. and Gruber, Oliver and Eickhoff, Simon},
      title        = {{D}ifferential {R}esting-{S}tate {C}onnectivity {P}atterns
                      of the {R}ight {A}nterior and {P}osterior {D}orsolateral
                      {P}refrontal {C}ortices ({DLPFC}) in {S}chizophrenia},
      journal      = {Frontiers in psychiatry},
      volume       = {9},
      issn         = {1664-0640},
      address      = {Lausanne},
      publisher    = {Frontiers Research Foundation},
      reportid     = {FZJ-2018-03236},
      pages        = {211},
      year         = {2018},
      abstract     = {In schizophrenia (SCZ), dysfunction of the dorsolateral
                      prefrontal cortex (DLPFC) has been linked to the deficits in
                      executive functions and attention. It has been suggested
                      that, instead of considering the right DLPFC as a cohesive
                      functional entity, it can be divided into two parts
                      (anterior and posterior) based on its whole-brain
                      connectivity patterns. Given these two subregions'
                      differential association with cognitive processes, we
                      investigated the functional connectivity (FC) profile of
                      both subregions through resting-state data to determine
                      whether they are differentially affected in SCZ.
                      Resting-state magnetic resonance imaging (MRI) scans were
                      obtained from 120 patients and 172 healthy controls (HC) at
                      6 different MRI sites. The results showed differential FC
                      patterns for the anterior and posterior parts of the right
                      executive control-related DLPFC in SCZ with the parietal,
                      the temporal and the cerebellar regions, along with a
                      convergent reduction of connectivity with the striatum and
                      the occipital cortex. An increased psychopathology level was
                      linked to a higher difference in posterior vs. anterior FC
                      for the left IFG/anterior insula, regions involved in
                      higher-order cognitive processes. In sum, the current
                      analysis demonstrated that even between two neighboring
                      clusters connectivity could be differentially disrupted in
                      SCZ. Lacking the necessary anatomical specificity, such
                      notions may in fact be detrimental to a proper understanding
                      of SCZ pathophysiology.},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572) / KFO 241 -
                      Genotyp-Phänotypbeziehungen und Neurobiologie des
                      longitudinalen Psychoseverlaufs (160201488)},
      pid          = {G:(DE-HGF)POF3-572 / G:(GEPRIS)160201488},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29892234},
      UT           = {WOS:000433187000001},
      doi          = {10.3389/fpsyt.2018.00211},
      url          = {https://juser.fz-juelich.de/record/847915},
}