TY  - JOUR
AU  - Kutovyi, Y.
AU  - Zadorozhnyi, I.
AU  - Hlukhova, H.
AU  - Handziuk, V.
AU  - Petrychuk, M.
AU  - Ivanchuk, Andriy
AU  - Vitusevich, S.
TI  - Origin of noise in liquid-gated Si nanowire troponin biosensors
JO  - Nanotechnology
VL  - 29
IS  - 17
SN  - 1361-6528
CY  - Bristol
PB  - IOP Publ.
M1  - FZJ-2018-03238
SP  - 175202 -1-11
PY  - 2018
AB  - Liquid-gated Si nanowire field-effect transistor (FET) biosensors are fabricated using a complementary metal-oxide-semiconductor-compatible top-down approach. The transport and noise properties of the devices reflect the high performance of the FET structures, which allows label-free detection of cardiac troponin I (cTnI) molecules. Moreover, after removing the troponin antigens the structures demonstrate the same characteristics as before cTnI detection, indicating the reusable operation of biosensors. Our results show that the additional noise is related to the troponin molecules and has characteristics which considerably differ from those usually recorded for conventional FETs without target molecules. We describe the origin of the noise and suggest that noise spectroscopy represents a powerful tool for understanding molecular dynamic processes in nanoscale FET-based biosensors.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000426737300001
C6  - pmid:29446349
DO  - DOI:10.1088/1361-6528/aaaf9e
UR  - https://juser.fz-juelich.de/record/847917
ER  -