TY  - JOUR
AU  - Palomero-Gallagher, Nicola
AU  - Hoffstaedter, Felix
AU  - Mohlberg, Hartmut
AU  - Eickhoff, Simon
AU  - Amunts, Katrin
AU  - Zilles, Karl
TI  - Human Pregenual Anterior Cingulate Cortex: Structural, Functional, and Connectional Heterogeneity
JO  - Cerebral cortex
VL  - 29
IS  - 6
SN  - 1460-2199
CY  - Oxford
PB  - Oxford Univ. Press
M1  - FZJ-2018-03306
SP  - 2552-2574
PY  - 2018
N1  - This study was partially supported by the European Union’s Horizon 2020 Research and Innovation Programme under Grant Agreement No. 785907 (HBP SGA2), the National Institute of Mental Health (R01-MH074457), and the Helmholtz Portfolio Theme “Supercomputing and Modeling for the Human Brain.”
AB  - The human pregenual anterior cingulate cortex (pACC) encompasses 7 distinct cyto- and receptorarchitectonic areas. We lack a detailed understanding of the functions in which they are involved, and stereotaxic maps are not available. We present an integrated structural/functional map of pACC based on probabilistic cytoarchitectonic mapping and meta-analytic connectivity modeling and quantitative functional decoding. Due to the restricted spatial resolution of functional imaging data relative to the microstructural parcellation, areas p24a of the callosal sulcus and p24b on the surface of the cingulate gyrus were merged into a "gyral component" (p24ab) of area p24, and areas pv24c, pd24cv, and pd24cd, located within the cingulate sulcus were merged into a "sulcal component" (p24c) for meta-analytic analysis. Area p24ab was specifically associated with interoception, p24c with the inhibition of action, and p32, which was also activated by emotion induction tasks pertaining negatively valenced stimuli, with the ability to experience empathy. Thus, area p32 could be classified as cingulate association cortex playing a crucial role in the cognitive regulation of emotion. By this spectrum of functions, pACC is a structurally and functionally heterogeneous region, clearly differing from other parts of the anterior and middle cingulate cortex.
LB  - PUB:(DE-HGF)16
C6  - pmid:29850806
UR  - <Go to ISI:>//WOS:000482132400018
DO  - DOI:10.1093/cercor/bhy124
UR  - https://juser.fz-juelich.de/record/847998
ER  -