000848142 001__ 848142
000848142 005__ 20240619091237.0
000848142 0247_ $$2Handle$$a2128/19397
000848142 0247_ $$2URN$$aurn:nbn:de:0001-2018080908
000848142 0247_ $$2ISSN$$a1866-1807
000848142 020__ $$a978-3-95806-332-7
000848142 037__ $$aFZJ-2018-03414
000848142 041__ $$aEnglish
000848142 1001_ $$0P:(DE-HGF)0$$aTran, Anh Quang$$b0$$eCorresponding author$$ufzj
000848142 245__ $$aControl of neuron adhesion by metal nanoparticles$$f2013-10-14 - 2018-05-25
000848142 260__ $$aJülich$$bForschungszentrum Jülich GmbH Zentralbibliothek, Verlag$$c2018
000848142 300__ $$aVIII, 108 S.
000848142 3367_ $$2DataCite$$aOutput Types/Dissertation
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000848142 3367_ $$2ORCID$$aDISSERTATION
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000848142 3367_ $$02$$2EndNote$$aThesis
000848142 3367_ $$0PUB:(DE-HGF)11$$2PUB:(DE-HGF)$$aDissertation / PhD Thesis$$bphd$$mphd$$s1532001159_28495
000848142 3367_ $$2DRIVER$$adoctoralThesis
000848142 4900_ $$aSchriften des Forschungszentrums Jülich. Reihe Schlüsseltechnologien / Key Technologies$$v171
000848142 502__ $$aRWTH Aachen, Diss., 2018$$bDr.$$cRWTH Aachen$$d2018
000848142 520__ $$aThe interaction between neurons and nanostructured materials is an increasing interest due to the possibility to manipulate the cells on the length scale of an individual biomolecule. A comprehensive understanding of neuron adhesion to non-biomaterials opens promising strategies to design neuronal network and for neuron-electrode integration. The neuronal adhesion can be mediated by specific receptor-ligand or non-specific interactions. The specific cell adhesion is often associated with the interactions between cell surface receptors (integrins)and their respective ligands from the extra cellular matrix (ECM) components or between hemophilic neuronal cell adhesion molecules (NCAMs) for cell-cell interactions. The nonspecific cell adhesion is mainly induced by electrostatic interactions. NCAMs are associated with the negatively charge polysialic acid (PSA) and are known to be crucial for regulating neuronal adhesion. Previously, the chemical ligand 11-amino-1-undecanethiol (AUT)possessing positively charged terminals have been used to functionalize gold nanoparticles(AuNPs) on the substrate for tuning the neuron adhesion and neurite outgrowth. However, the preparation of cell culture samples has been restricted to the immobilization of disordered AuNPs only. Moreover, it has been found that the attachment of these AuNPs on the surface has been instable during long time cell culture, which results in particle aggregation and cytotoxicity due to particle uptake. Although the cell adhesion is obviously mediated by the electrostatic interactions, further studies to understand how charges and mechanical properties of the substrates affect the cell adhesion and neurite outgrowth are still missing. In this work, the block copolymer micelle nanolithography is used to synthesize both ordered and disordered AuNP arrays of different sizes and densities. Moreover, weakly bound (WB) and strongly bound(SB) AuNPs on the substrates can be obtained by tuning the oxygen plasma exposure time. The AuNPs are used as nanoplatforms to carry the AUT ligands, while the background is blocked by cell aversive molecules of 2-[methoxyl(polyethyleneoxy)6-9-propyl]trichlosilane (PEG). [...]
000848142 536__ $$0G:(DE-HGF)POF3-552$$a552 - Engineering Cell Function (POF3-552)$$cPOF3-552$$fPOF III$$x0
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000848142 915__ $$0LIC:(DE-HGF)CCBY4$$2HGFVOC$$aCreative Commons Attribution CC BY 4.0
000848142 9141_ $$y2018
000848142 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-HGF)0$$aForschungszentrum Jülich$$b0$$kFZJ
000848142 9131_ $$0G:(DE-HGF)POF3-552$$1G:(DE-HGF)POF3-550$$2G:(DE-HGF)POF3-500$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bKey Technologies$$lBioSoft – Fundamentals for future Technologies in the fields of Soft Matter and Life Sciences$$vEngineering Cell Function$$x0
000848142 920__ $$lyes
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