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@PHDTHESIS{Tran:848142,
      author       = {Tran, Anh Quang},
      title        = {{C}ontrol of neuron adhesion by metal nanoparticles},
      volume       = {171},
      school       = {RWTH Aachen},
      type         = {Dr.},
      address      = {Jülich},
      publisher    = {Forschungszentrum Jülich GmbH Zentralbibliothek, Verlag},
      reportid     = {FZJ-2018-03414},
      isbn         = {978-3-95806-332-7},
      series       = {Schriften des Forschungszentrums Jülich. Reihe
                      Schlüsseltechnologien / Key Technologies},
      pages        = {VIII, 108 S.},
      year         = {2018},
      note         = {RWTH Aachen, Diss., 2018},
      abstract     = {The interaction between neurons and nanostructured
                      materials is an increasing interest due to the possibility
                      to manipulate the cells on the length scale of an individual
                      biomolecule. A comprehensive understanding of neuron
                      adhesion to non-biomaterials opens promising strategies to
                      design neuronal network and for neuron-electrode
                      integration. The neuronal adhesion can be mediated by
                      specific receptor-ligand or non-specific interactions. The
                      specific cell adhesion is often associated with the
                      interactions between cell surface receptors (integrins)and
                      their respective ligands from the extra cellular matrix
                      (ECM) components or between hemophilic neuronal cell
                      adhesion molecules (NCAMs) for cell-cell interactions. The
                      nonspecific cell adhesion is mainly induced by electrostatic
                      interactions. NCAMs are associated with the negatively
                      charge polysialic acid (PSA) and are known to be crucial for
                      regulating neuronal adhesion. Previously, the chemical
                      ligand 11-amino-1-undecanethiol (AUT)possessing positively
                      charged terminals have been used to functionalize gold
                      nanoparticles(AuNPs) on the substrate for tuning the neuron
                      adhesion and neurite outgrowth. However, the preparation of
                      cell culture samples has been restricted to the
                      immobilization of disordered AuNPs only. Moreover, it has
                      been found that the attachment of these AuNPs on the surface
                      has been instable during long time cell culture, which
                      results in particle aggregation and cytotoxicity due to
                      particle uptake. Although the cell adhesion is obviously
                      mediated by the electrostatic interactions, further studies
                      to understand how charges and mechanical properties of the
                      substrates affect the cell adhesion and neurite outgrowth
                      are still missing. In this work, the block copolymer micelle
                      nanolithography is used to synthesize both ordered and
                      disordered AuNP arrays of different sizes and densities.
                      Moreover, weakly bound (WB) and strongly bound(SB) AuNPs on
                      the substrates can be obtained by tuning the oxygen plasma
                      exposure time. The AuNPs are used as nanoplatforms to carry
                      the AUT ligands, while the background is blocked by cell
                      aversive molecules of
                      2-[methoxyl(polyethyleneoxy)6-9-propyl]trichlosilane (PEG).
                      [...]},
      cin          = {ICS-8},
      cid          = {I:(DE-Juel1)ICS-8-20110106},
      pnm          = {552 - Engineering Cell Function (POF3-552)},
      pid          = {G:(DE-HGF)POF3-552},
      typ          = {PUB:(DE-HGF)3 / PUB:(DE-HGF)11},
      urn          = {urn:nbn:de:0001-2018080908},
      url          = {https://juser.fz-juelich.de/record/848142},
}