TY  - JOUR
AU  - Stegmayr, Carina
AU  - Stoffels, Gabriele
AU  - Rota Kops, Elena
AU  - Lohmann, Philipp
AU  - Galldiks, Norbert
AU  - Shah, Nadim J.
AU  - Neumaier, Bernd
AU  - Langen, Karl-Josef
TI  - Influence of Dexamethasone on O-(2-[18F]-Fluoroethyl)-l-Tyrosine Uptake in the Human Brain and Quantification of Tumor Uptake
JO  - Molecular imaging & biology
VL  - 21
IS  - 1
SN  - 1860-2002
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - FZJ-2018-03453
SP  - 168–174
PY  - 2019
AB  - PurposeO-(2-[18F]fluoroethyl)-l-tyrosine ([18F]FET) is an established positron emission tomography (PET) tracer for brain tumor imaging. This study explores the influence of dexamethasone therapy on [18F]FET uptake in the normal brain and its influence on the maximum and mean tumor-to-brain ratio (TBR).Procedures[18F]FET PET scans of 160 brain tumor patients were evaluated (80 dexamethasone treated, 80 untreated; each group with 40 men/40 women). The standardized uptake value of [18F]FET uptake in the normal brain (SUVbrain) in the different groups was compared. Nine patients were examined repeatedly with and without dexamethasone therapy.ResultsSUVbrain of [18F]FET uptake was significantly higher in dexamethasone-treated patients than in untreated patients (SUVbrain 1.33 ± 0.1 versus 1.06 ± 0.16 in male and 1.45 ± 0.25 versus 1.31 ± 0.28 in female patients). Similar results were observed in patients with serial PET scans. Furthermore, compared to men, a significantly higher SUVbrain was found in women, both with and without dexamethasone treatment. There were no significant differences between the different groups for TBRmax and TBRmean, which could have been masked by the high standard deviation. In a patient with a stable brain metastasis investigated twice with and without dexamethasone, the TBRmax and the biological tumor volume (BTV) decreased considerably after dexamethasone due to an increased SUVbrain.ConclusionDexamethasone treatment appears to increase the [18F]FET uptake in the normal brain. An effect on TBRmax, TBRmean, and BTV cannot be excluded which should be considered especially for treatment monitoring and the estimation of BTV using [18F]FET PET.
LB  - PUB:(DE-HGF)16
C6  - pmid:29845426
UR  - <Go to ISI:>//WOS:000458989800019
DO  - DOI:10.1007/s11307-018-1221-z
UR  - https://juser.fz-juelich.de/record/848187
ER  -