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@ARTICLE{Stegmayr:848187,
      author       = {Stegmayr, Carina and Stoffels, Gabriele and Rota Kops,
                      Elena and Lohmann, Philipp and Galldiks, Norbert and Shah,
                      Nadim J. and Neumaier, Bernd and Langen, Karl-Josef},
      title        = {{I}nfluence of {D}examethasone on
                      {O}-(2-[18{F}]-{F}luoroethyl)-l-{T}yrosine {U}ptake in the
                      {H}uman {B}rain and {Q}uantification of {T}umor {U}ptake},
      journal      = {Molecular imaging $\&$ biology},
      volume       = {21},
      number       = {1},
      issn         = {1860-2002},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2018-03453},
      pages        = {168–174},
      year         = {2019},
      abstract     = {PurposeO-(2-[18F]fluoroethyl)-l-tyrosine ([18F]FET) is an
                      established positron emission tomography (PET) tracer for
                      brain tumor imaging. This study explores the influence of
                      dexamethasone therapy on [18F]FET uptake in the normal brain
                      and its influence on the maximum and mean tumor-to-brain
                      ratio (TBR).Procedures[18F]FET PET scans of 160 brain tumor
                      patients were evaluated (80 dexamethasone treated, 80
                      untreated; each group with 40 men/40 women). The
                      standardized uptake value of [18F]FET uptake in the normal
                      brain (SUVbrain) in the different groups was compared. Nine
                      patients were examined repeatedly with and without
                      dexamethasone therapy.ResultsSUVbrain of [18F]FET uptake was
                      significantly higher in dexamethasone-treated patients than
                      in untreated patients (SUVbrain 1.33 ± 0.1 versus
                      1.06 ± 0.16 in male and 1.45 ± 0.25 versus
                      1.31 ± 0.28 in female patients). Similar results were
                      observed in patients with serial PET scans. Furthermore,
                      compared to men, a significantly higher SUVbrain was found
                      in women, both with and without dexamethasone treatment.
                      There were no significant differences between the different
                      groups for TBRmax and TBRmean, which could have been masked
                      by the high standard deviation. In a patient with a stable
                      brain metastasis investigated twice with and without
                      dexamethasone, the TBRmax and the biological tumor volume
                      (BTV) decreased considerably after dexamethasone due to an
                      increased SUVbrain.ConclusionDexamethasone treatment appears
                      to increase the [18F]FET uptake in the normal brain. An
                      effect on TBRmax, TBRmean, and BTV cannot be excluded which
                      should be considered especially for treatment monitoring and
                      the estimation of BTV using [18F]FET PET.},
      cin          = {INM-3 / INM-4 / INM-5 / INM-11},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406 / I:(DE-Juel1)INM-4-20090406 /
                      I:(DE-Juel1)INM-5-20090406 / I:(DE-Juel1)INM-11-20170113},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29845426},
      UT           = {WOS:000458989800019},
      doi          = {10.1007/s11307-018-1221-z},
      url          = {https://juser.fz-juelich.de/record/848187},
}