% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Goldbrunner:849537,
      author       = {Goldbrunner, Roland and Ruge, Maximilian and Kocher, Martin
                      and Lucas, Carolin Weiß and Galldiks, Norbert and Grau,
                      Stefan},
      title        = {{T}he treatment of gliomas in adulthood},
      journal      = {Deutsches Ärzteblatt international},
      volume       = {115},
      number       = {20-21},
      issn         = {1866-0452},
      address      = {Köln},
      publisher    = {Dt. Ärzte-Verl.},
      reportid     = {FZJ-2018-03720},
      pages        = {356-364},
      year         = {2018},
      abstract     = {Background: Gliomas are the most common intrinsic tumors of
                      the brain, with an incidence of 6 per 100 000 persons per
                      year. Recent years have seen marked changes in the diagnosis
                      and treatment of gliomas, with molecular parameters now
                      being an integral part of the diagnostic evaluation.Methods:
                      This review is based on pertinent articles retrieved by a
                      selective search in PubMed, with special attention to the
                      new WHO glioma classification.Results: The classification of
                      gliomas on the basis of additional molecular parameters
                      enables more accurate prognostication and serves as a basis
                      for therapeutic decision-making and treatment according to
                      precisely specified algorithms. PET scanning with
                      18F-fluoroethyl tyrosine and 11C-methionine for the
                      measurement of metabolic activity in gliomas has further
                      refined the diagnostic evaluation. The median overall
                      survival of patients with glioblastoma who have undergone
                      resection of all tumor tissue with a disrupted blood–brain
                      barrier (i.e., all contrast-enhancing tumor tissue) has been
                      prolonged to up to 20 months. The 5-year survival of
                      patients with WHO grade II gliomas is now as high as $97\%$
                      after near-total resection. The surgical resection of all
                      contrast-enhancing tumor tissue and subsequent radiotherapy
                      and chemotherapy remain the key elements of treatment. New
                      surgical strategies and new methods of planning radiotherapy
                      have made these techniques safer and more effective. The
                      percutaneous application of tumor-treating fields is a new
                      therapeutic option that has gained a degree of acceptance.
                      Accompanying measures such as psycho-oncology and palliative
                      care are very important for patients and should be
                      considered mandatory.Conclusion: The consistent application
                      of the existing multimodal treatment options for glioma has
                      led in recent years to improved survival. Areas of important
                      current and future scientific activity include immunotherapy
                      and targeted and combined chemotherapy, as well as altered
                      neurocognition, modern approaches to palliative care, and
                      complementary therapies.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29914619},
      UT           = {WOS:000435360200008},
      doi          = {10.3238/arztebl.2018.0356},
      url          = {https://juser.fz-juelich.de/record/849537},
}