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@INPROCEEDINGS{Schrader:849541,
      author       = {Schrader, Tobias Erich and Ostermann, Andreas and Longo,
                      Marialucia and Monkenbusch, Michael and Laatsch, Bernhard
                      and Jüttner and Petry and Richter, Dieter},
      title        = {{D}rug development using information from {N}eutron protein
                      crystallography},
      reportid     = {FZJ-2018-03724},
      year         = {2017},
      abstract     = {Neutron protein crystallography is a technique which can
                      readily report on the hydrogen atom positions in proteins.
                      This is in some cases valuable information on drug target
                      proteins and their hydrogen bonding with substrates and
                      inhibitors. Other main scientific questions addressed are:
                      protonation states of amino acids in intermediate states of
                      the catalytic process and determining the correct structure
                      of metallo-proteins which are subjected to reduction due to
                      the radiation damage caused by x-rays. As an example for a
                      neutron diffractometer, the instrument BIODIFF is
                      introduced: It is a joint project of the Jülich Centre for
                      Neutron Science (JCNS) and the FRM II. BIODIFF is designed
                      as a monochromatic instrument with a narrow wavelength
                      spread of less than 3 $\%.$ To cover a large solid angle the
                      main detector of BIODIFF consists of a neutron imaging plate
                      in a cylindrical geometry with online read-out capability.
                      The main advantage of BIODIFF is the possibility to adapt
                      the wavelength to the size of the unit cell of the sample
                      crystal while operating with a clean monochromatic beam that
                      keeps the background level low.In this contribution, a
                      review of most recent application examples of neutron
                      protein crystallography for drug development is given.
                      Especially the need for large protein crystals (typically >
                      0.5 mm3 in volume) is addressed.},
      month         = {Jun},
      date          = {2017-06-27},
      organization  = {Neutrons for Health Conference, Bad
                       Reichenhall (Germany), 27 Jun 2017 - 30
                       Jun 2017},
      subtyp        = {After Call},
      cin          = {JCNS (München) ; Jülich Centre for Neutron Science JCNS
                      (München) ; JCNS-FRM-II / Neutronenstreuung ; JCNS-1 /
                      JCNS-2 / ZEA-1},
      cid          = {I:(DE-Juel1)JCNS-FRM-II-20110218 /
                      I:(DE-Juel1)JCNS-1-20110106 / I:(DE-Juel1)JCNS-2-20110106 /
                      I:(DE-Juel1)ZEA-1-20090406},
      pnm          = {6G4 - Jülich Centre for Neutron Research (JCNS) (POF3-623)
                      / 6215 - Soft Matter, Health and Life Sciences (POF3-621) /
                      6G15 - FRM II / MLZ (POF3-6G15)},
      pid          = {G:(DE-HGF)POF3-6G4 / G:(DE-HGF)POF3-6215 /
                      G:(DE-HGF)POF3-6G15},
      experiment   = {EXP:(DE-MLZ)BIODIFF-20140101},
      typ          = {PUB:(DE-HGF)6},
      url          = {https://juser.fz-juelich.de/record/849541},
}