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@ARTICLE{Sueck:849598,
      author       = {Sueck, Franziska and Poór, Miklós and Faisal, Zelma and
                      Gertzen, Christoph and Cramer, Benedikt and Lemli, Beáta
                      and Kunsági-Máté, Sándor and Gohlke, Holger and Humpf,
                      Hans-Ulrich},
      title        = {{I}nteraction of {O}chratoxin {A} and {I}ts {T}hermal
                      {D}egradation {P}roduct 2′{R}-{O}chratoxin {A} with
                      {H}uman {S}erum {A}lbumin},
      journal      = {Toxins},
      volume       = {10},
      number       = {7},
      issn         = {2072-6651},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {FZJ-2018-03777},
      pages        = {256 -},
      year         = {2018},
      abstract     = {Ochratoxin A (OTA) is a toxic secondary metabolite produced
                      by several fungal species of the genus Penicillium and
                      Aspergillus. 2′R-Ochratoxin A (2′R-OTA) is a thermal
                      isomerization product of OTA formed during food processing
                      at high temperatures. Both compounds are detectable in human
                      blood in concentrations between 0.02 and 0.41 µg/L with
                      2′R-OTA being only detectable in the blood of coffee
                      drinkers. Humans have approximately a fifty-fold higher
                      exposure through food consumption to OTA than to 2′R-OTA.
                      In human blood, however, the differences between the
                      concentrations of the two compounds is, on average, only a
                      factor of two. To understand these unexpectedly high
                      2′R-OTA concentrations found in human blood, the affinity
                      of this compound to the most abundant protein in human blood
                      the human serum albumin (HSA) was studied and compared to
                      that of OTA, which has a well-known high binding affinity.
                      Using fluorescence spectroscopy, equilibrium dialysis,
                      circular dichroism (CD), high performance affinity
                      chromatography (HPAC), and molecular modelling experiments,
                      the affinities of OTA and 2′R-OTA to HSA were determined
                      and compared with each other. For the affinity of HSA
                      towards OTA, a logK of 7.0–7.6 was calculated, while for
                      its thermally produced isomer 2′R-OTA, a lower, but still
                      high, logK of 6.2–6.4 was determined. The data of all
                      experiments showed consistently that OTA has a higher
                      affinity to HSA than 2′R-OTA. Thus, differences in the
                      affinity to HSA cannot explain the relatively high levels of
                      2′R-OTA found in human blood samples},
      cin          = {JSC / NIC / ICS-6},
      ddc          = {610},
      cid          = {I:(DE-Juel1)JSC-20090406 / I:(DE-Juel1)NIC-20090406 /
                      I:(DE-Juel1)ICS-6-20110106},
      pnm          = {511 - Computational Science and Mathematical Methods
                      (POF3-511) / 574 - Theory, modelling and simulation
                      (POF3-574) / 561 - Biological Key Regulators and Small
                      Chemical Compounds (POF3-561) / Forschergruppe Gohlke
                      $(hkf7_20170501)$},
      pid          = {G:(DE-HGF)POF3-511 / G:(DE-HGF)POF3-574 /
                      G:(DE-HGF)POF3-561 / $G:(DE-Juel1)hkf7_20170501$},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29932113},
      UT           = {WOS:000442594000004},
      doi          = {10.3390/toxins10070256},
      url          = {https://juser.fz-juelich.de/record/849598},
}