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@ARTICLE{Langen:849853,
      author       = {Langen, Karl-Josef and Galldiks, Norbert},
      title        = {{U}pdate on amino acid {PET} of brain tumours},
      journal      = {Current opinion in neurology},
      volume       = {31},
      number       = {4},
      issn         = {1350-7540},
      address      = {London},
      publisher    = {Lippincott Williams $\&$ Wilkins},
      reportid     = {FZJ-2018-03955},
      pages        = {354 - 361},
      year         = {2018},
      abstract     = {Purpose of review The aim of this study was to give an
                      update on the emerging role of PET using radiolabelled amino
                      acids in the diagnostic workup and management of patients
                      with cerebral gliomas and brain metastases.Recent findings
                      Numerous studies have demonstrated the potential of PET
                      using radiolabelled amino acids for differential diagnosis
                      of brain tumours, delineation of tumour extent for treatment
                      planning and biopsy guidance, differentiation between tumour
                      progression and recurrence versus treatment-related changes,
                      and for monitoring of therapy. The Response Assessment in
                      Neuro-Oncology (RANO) working group – an international
                      effort to develop new standardized response criteria for
                      clinical trials in brain tumours – has recently
                      recommended the use of amino acid PET imaging for brain
                      tumour management in addition to MRI at every stage of
                      disease. With the introduction of F-18 labelled amino acids,
                      a broader clinical application has become possible, but is
                      still hampered by the lack of regulatory approval and of
                      reimbursement in many countries.Summary PET using
                      radiolabelled amino acids is a rapidly evolving method that
                      can significantly enhance the diagnostic value of MRI in
                      brain tumours. Current developments suggest that this
                      imaging technique will become an indispensable tool in
                      neuro-oncological centres in the near future.},
      cin          = {INM-4 / INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-4-20090406 / I:(DE-Juel1)INM-3-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29952832},
      UT           = {WOS:000455659300002},
      doi          = {10.1097/WCO.0000000000000574},
      url          = {https://juser.fz-juelich.de/record/849853},
}