000849924 001__ 849924
000849924 005__ 20240619083547.0
000849924 0247_ $$2Handle$$a2128/20995
000849924 037__ $$aFZJ-2018-04020
000849924 041__ $$aEnglish
000849924 1001_ $$0P:(DE-Juel1)131034$$aWiegand, Simone$$b0$$eCorresponding author$$ufzj
000849924 1112_ $$aTwentieth Symposium on Thermophysical Properties$$cBoulder$$d2018-06-24 - 2018-06-29$$wUSA
000849924 245__ $$aHow does the hydration layer influence the thermodiffusion of aqueous systems?
000849924 260__ $$c2018
000849924 3367_ $$033$$2EndNote$$aConference Paper
000849924 3367_ $$2DataCite$$aOther
000849924 3367_ $$2BibTeX$$aINPROCEEDINGS
000849924 3367_ $$2DRIVER$$aconferenceObject
000849924 3367_ $$2ORCID$$aLECTURE_SPEECH
000849924 3367_ $$0PUB:(DE-HGF)6$$2PUB:(DE-HGF)$$aConference Presentation$$bconf$$mconf$$s1545289867_26509$$xInvited
000849924 520__ $$aThermodiffusion, also called the Ludwig-Soret effect, has gained popularity in recent years as an analytical approach (Microscale Thermophoresis (MST)) to monitor binding reactions in biological molecules that are relevant in pharmaceutical applications. The success of this technique relies on the superb sensitivity of thermodiffusion to changes in the hydration layer around a solute. While for non-polar systems the « heat of transfer » concept has been successfully applied, the mechanism in aqueous systems is more complicated due to charge effects and strong specific cross interactions. On the other hand a detailed understanding of aqueous systems would be valuable due to important applications in biotechnology. To get a better comprehension of the underlying processes we systematically investigated various small molecules and charged colloids by a holographic grating method called infrared Thermal Diffusion Forced Rayleigh Scattering (IR-TDFRS). We elucidate the often found typical temperature dependence of the Soret coefficient of solute molecules in water. From a literature survey and measurements of hydrogen bond formers like amides in water we claim that this simple empirical approach to describe the temperature dependence breaks down at higher solute concentrations, when interactions between different solute molecules start to play a role. Additionally the concept also requires a hydrogen bond network without micro-heterogeneities or cage structures. Performing temperature and concentration dependent measurements, we observe a clear correlation of the temperature and concentration dependence of the Soret coefficient with the hydrophilicity, which can be quantitatively described by the logarithm of the 1-octanol/water partition coefficient P, which is a measure for the hydrophilicity/hydrophobicity balance of a solute. This coefficient is often used to model the transport of a compound in the environment or to screen for potential pharmaceutical compounds. The clear correlation between log P and the temperature sensitivity of the Soret coefficient open a route for a more sophisticated hydrophilicity scale.
000849924 536__ $$0G:(DE-HGF)POF3-551$$a551 - Functional Macromolecules and Complexes (POF3-551)$$cPOF3-551$$fPOF III$$x0
000849924 8564_ $$uhttps://juser.fz-juelich.de/record/849924/files/Wiegand-How%20does%20the%20hydration%20layer.pdf$$yOpenAccess
000849924 909CO $$ooai:juser.fz-juelich.de:849924$$pdriver$$pVDB$$popen_access$$popenaire
000849924 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131034$$aForschungszentrum Jülich$$b0$$kFZJ
000849924 9131_ $$0G:(DE-HGF)POF3-551$$1G:(DE-HGF)POF3-550$$2G:(DE-HGF)POF3-500$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bKey Technologies$$lBioSoft – Fundamentals for future Technologies in the fields of Soft Matter and Life Sciences$$vFunctional Macromolecules and Complexes$$x0
000849924 9141_ $$y2018
000849924 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000849924 920__ $$lyes
000849924 9201_ $$0I:(DE-Juel1)ICS-3-20110106$$kICS-3$$lWeiche Materie $$x0
000849924 9801_ $$aFullTexts
000849924 980__ $$aconf
000849924 980__ $$aVDB
000849924 980__ $$aUNRESTRICTED
000849924 980__ $$aI:(DE-Juel1)ICS-3-20110106