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@ARTICLE{Conwell:849941,
      author       = {Conwell, K. and von Reutern, Boris and Richter, Nils and
                      Kukolja, J. and Fink, G. R. and Onur, Özgür},
      title        = {{T}est-retest variability of resting-state networks in
                      healthy aging and prodromal {A}lzheimer's disease},
      journal      = {NeuroImage: Clinical},
      volume       = {19},
      issn         = {2213-1582},
      address      = {[Amsterdam u.a.]},
      publisher    = {Elsevier},
      reportid     = {FZJ-2018-04036},
      pages        = {948 - 962},
      year         = {2018},
      abstract     = {In recent years, changes in resting-state networks (RSN),
                      identified by functional magnetic resonance imaging (fMRI),
                      have gained increasing attention as potential biomarkers and
                      trackers of neurological disorders such as Alzheimer's
                      disease (AD). Intersession reliability of RSN is fundamental
                      to this approach.In this study, we investigated the
                      test-retest reliability of three memory related RSN (i.e.,
                      the default mode, salience, and executive control network)
                      in 15 young, 15 healthy seniors (HS), and 15 subjects
                      affected by mild cognitive impairment (MCI) with positive
                      biomarkers suggestive of incipient AD (6 females each). FMRI
                      was conducted on three separate occasions. Independent
                      Component Analysis decomposed the resting-state data into
                      RSNs. Comparisons of variation in functional connectivity
                      between groups were made applying different thresholds in an
                      explorative approach. Intersession test-retest reliability
                      was evaluated by intraclass correlation coefficient (ICC)
                      comparisons. To assess the effect of gray matter volume
                      loss, motion, cerebrospinal fluid based biomarkers and the
                      time gap between sessions on intersession variation, the
                      former four were correlated separately with the latter.Data
                      showed that i) young subjects ICCs (relative to
                      HS/MCI-subjects) had higher intersession reliability, ii)
                      stringent statistical thresholds need to be applied to
                      prevent false-positives, iii) both HS and MCI-subjects
                      (relative to young) showed significantly more clusters of
                      intersession variation in all three RSN, iv) while
                      intersession variation was highly correlated with head
                      motion, it was also correlated with biomarkers (especially
                      phospho-tau), the time gap between sessions and local GMV.
                      Results indicate that time gaps between sessions should be
                      kept constant and that head motion must be taken into
                      account when using RSN to assess aging and
                      neurodegeneration. In patients with prodromal AD, re-test
                      reliability may be increased by accouting for overall
                      disease burden by including biomarkers of neuronal injury
                      (especially phospho-tau) in statistical analyses. Local
                      atrophy however, does not seem to play a major role in
                      regards to reliability, but should be used as covariate
                      depending on the research question.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30003032},
      UT           = {WOS:000441936300098},
      doi          = {10.1016/j.nicl.2018.06.016},
      url          = {https://juser.fz-juelich.de/record/849941},
}