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@ARTICLE{Rogall:849944,
      author       = {Rogall, Rebecca and Rabenstein, Monika and Vay, Sabine and
                      Bach, Annika and Pikhovych, Anton and Baermann, Johannes and
                      Hoehn, Mathias and Couillard-Despres, Sébastien and Fink,
                      Gereon Rudolf and Schroeter, Michael and Rueger, Maria
                      Adele},
      title        = {{B}ioluminescence imaging visualizes osteopontin-induced
                      neurogenesis and neuroblast migration in the mouse brain
                      after stroke},
      journal      = {Stem cell research $\&$ therapy},
      volume       = {9},
      issn         = {1757-6512},
      address      = {London},
      publisher    = {BioMed Central},
      reportid     = {FZJ-2018-04039},
      pages        = {183},
      year         = {2018},
      abstract     = {BackgroundOsteopontin (OPN), an acidic phosphoglycoprotein,
                      is upregulated in the brain after cerebral ischemia. We
                      previously reported that OPN supports migration, survival,
                      and proliferation of neural stem cells (NSC) in primary cell
                      culture, as well as their differentiation into neurons. We
                      here analyzed the effects of OPN on neuroblasts in vivo in
                      the context of cerebral ischemia.MethodsTransgenic mice
                      expressing luciferase under the control of the
                      neuroblast-specific doublecortin (DCX)-promoter, allowing
                      visualization of neuroblasts in vivo using bioluminescence
                      imaging (BLI), were injected with OPN
                      intracerebroventricularly while control mice were injected
                      with vehicle buffer. To assess the effects of OPN after
                      ischemia, additional mice were subjected to photothrombosis
                      and injected with either OPN or vehicle.ResultsOPN enhanced
                      the migration of neuroblasts both in the healthy brain and
                      after ischemia, as quantified by BLI in vivo. Moreover, the
                      number of neural progenitors was increased following OPN
                      treatment, with the maximum effect on the second day after
                      OPN injection into the healthy brain, and 14 days after OPN
                      injection following ischemia. After ischemia, OPN
                      quantitatively promoted the endogenous, ischemia-induced
                      neuroblast expansion, and additionally recruited progenitors
                      from the contralateral hemisphere.ConclusionsOur results
                      strongly suggest that OPN constitutes a promising substance
                      for the targeted activation of neurogenesis in ischemic
                      stroke.},
      cin          = {INM-3},
      ddc          = {570},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29973246},
      UT           = {WOS:000437301100007},
      doi          = {10.1186/s13287-018-0927-9},
      url          = {https://juser.fz-juelich.de/record/849944},
}