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@INPROCEEDINGS{Longo:849968,
      author       = {Longo, Marialucia and Sebastiani, Federico and Paciaroni,
                      Alessandro and Orecchini, Andrea and Sacchetti, Francesco
                      and Petrillo, Caterina and Muthmann, Matthias and Texeira,
                      S. C. and de Francesco, A. and Comez, Lucia},
      title        = {{H}ydration-dependent dynamics of human telomeric
                      oligonucleotides investigated by inelastic neutron
                      scattering},
      reportid     = {FZJ-2018-04063},
      year         = {2017},
      abstract     = {The functionality of biomolecules, such as DNA, is related
                      not only to the structural but also to the dynamical
                      properties. The activation of fast structural fluctuations
                      on the pico- and nanosecond time windows enables slower
                      conformational rearrangements and provides a minimum degree
                      of flexibility required to carry out the biological
                      activity. Recently, the number of studies on guanine-rich
                      sequences at the end of telomeres is strongly increasing
                      because of their potential therapeutic target for cancer.
                      This kind of oligonucleotides can fold into a four-stranded
                      structure called G-quadruplex and then inhibit the activity
                      of telomerase, which is an enzyme responsible for the
                      immortalization of the cancer cells. In this context, an
                      inelastic neutron scattering study has been performed to
                      investigate how the hydration degree and the temperature
                      affect the thermal fluctuations of the intra-molecular
                      sequence d[AG3(AG3T2)3], which has been extensively used as
                      a model for human telomeres. A hydration-dependent dynamical
                      activation in weakly hydrated samples of oligonucleotides
                      was found showing a contribution from intra- and
                      inter-nucleotide dynamics.The trends of both amplitudes and
                      the characteristic timescales of the thermal fluctuations
                      point to a higher conformational flexibility of the human
                      telomeric sequence as compared to that of a long sequence of
                      DNA.},
      month         = {Jun},
      date          = {2017-06-27},
      organization  = {Neutrons for Health, Bad Reichenhall
                       (Germany), 27 Jun 2017 - 30 Jun 2017},
      subtyp        = {After Call},
      cin          = {JCNS-FRM-II / Neutronenstreuung ; JCNS-1},
      cid          = {I:(DE-Juel1)JCNS-FRM-II-20110218 /
                      I:(DE-Juel1)JCNS-1-20110106},
      pnm          = {6G15 - FRM II / MLZ (POF3-6G15) / 6G4 - Jülich Centre for
                      Neutron Research (JCNS) (POF3-623) / SINE2020 - World class
                      Science and Innovation with Neutrons in Europe 2020 –
                      SINE2020 (654000)},
      pid          = {G:(DE-HGF)POF3-6G15 / G:(DE-HGF)POF3-6G4 /
                      G:(EU-Grant)654000},
      experiment   = {EXP:(DE-MLZ)SPHERES-20140101},
      typ          = {PUB:(DE-HGF)24},
      url          = {https://juser.fz-juelich.de/record/849968},
}