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@ARTICLE{Markov:849981,
      author       = {Markov, Aleksandr and Maybeck, Vanessa and Wolf, Nikolaus
                      and Mayer, Dirk and Offenhäusser, Andreas and Wördenweber,
                      Roger},
      title        = {{E}ngineering of {N}euron {G}rowth and {E}nhancing
                      {C}ell-{C}hip {C}ommunication via {M}ixed {SAM}s},
      journal      = {ACS applied materials $\&$ interfaces},
      volume       = {10},
      number       = {22},
      issn         = {1944-8252},
      address      = {Washington, DC},
      publisher    = {Soc.},
      reportid     = {FZJ-2018-04076},
      pages        = {18507 - 18514},
      year         = {2018},
      abstract     = {The interface between cells and inorganic surfaces
                      represents one of the key elements for bioelectronics
                      experiments and applications ranging from cell cultures and
                      bioelectronics devices to medial implants. In the present
                      paper, we describe a way to tailor the biocompatibility of
                      substrates in terms of cell growth and to significantly
                      improve cell-chip communication, and we also demonstrate the
                      reusability of the substrates for cell experiments. All
                      these improvements are achieved by coating the substrates or
                      chips with a self-assembled monolayer (SAM) consisting of a
                      mixture of organic molecules,
                      (3-aminopropyl)-triethoxysilane (APTES) and
                      (3-glycidyloxypropyl)-trimethoxysilane (GLYMO). By varying
                      the ratio of these molecules, we are able to tune the cell
                      density and live/dead ratios of rat cortical neurons
                      cultured directly on the mixed SAM as well as neurons
                      cultured on protein-coated SAMs. Furthermore, the use of the
                      SAM leads to a significant improvement in cell-chip
                      communications. Action potential signals of up to 9.4± 0.6
                      mV (signal-to-noise ratio up to 47) are obtained for HL-1
                      cells on microelectrode arrays. Finally, we demonstrate that
                      the SAMs facilitates a reusability of the samples for all
                      cell experiments with little re-processing.},
      cin          = {ICS-8},
      ddc          = {540},
      cid          = {I:(DE-Juel1)ICS-8-20110106},
      pnm          = {552 - Engineering Cell Function (POF3-552)},
      pid          = {G:(DE-HGF)POF3-552},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29763286},
      UT           = {WOS:000434895500010},
      doi          = {10.1021/acsami.8b02948},
      url          = {https://juser.fz-juelich.de/record/849981},
}