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@ARTICLE{Rosjat:850281,
      author       = {Rosjat, Nils and Liu, Liqing and Wang, Bin A. and Popovych,
                      Svitlana and Tóth, Tibor and Viswanathan, Shivakumar and
                      Grefkes, Christian and Fink, Gereon R. and Daun, Silvia},
      title        = {{A}ging-associated changes of movement-related functional
                      connectivity in the human brain},
      journal      = {Neuropsychologia},
      volume       = {117},
      issn         = {0028-3932},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2018-04323},
      pages        = {520 - 529},
      year         = {2018},
      abstract     = {Motor performance declines with normal aging. Previous
                      neuroimaging work revealed aging-related general increases
                      in neural activity, especially in the prefrontal and
                      pre-motor areas, associated with a loss of hemispheric
                      lateralization. However, the functional mechanisms
                      underlying these changes and their relation to
                      aging-associated motor decline to date remain elusive.To
                      further elucidate the neural processes underlying
                      aging-related motor decline, we recorded EEG from younger
                      and older subjects while they performed a finger-tapping
                      task. As a measure of synchronization between motor areas,
                      we computed the inter-regional phase-locking value which
                      reflects functional connectivity between distinct neural
                      populations.Behavioral data revealed increased movement
                      times in older subjects. EEG data showed that phase locking
                      in the δ-θ frequencies is a general, age-independent
                      phenomenon underlying the execution of simple finger
                      movements. In stark contrast, the extent of synchronization
                      between motor areas significantly differed dependent upon
                      age of subjects: multiple additional intra- and
                      inter-hemispheric connections were observed in older
                      subjects. Our data shed light upon the results of previous
                      neuroimaging studies showing aging-related increases in
                      neural activation. In particular, data suggest that the
                      observed aging-dependent substantial intra- and
                      inter-hemispheric reorganization of connectivity between the
                      corresponding motor areas underlies the previously reported
                      loss of lateralization in older subjects. The changes
                      observed are likely to represent compensatory mechanisms
                      aiming at preserved task performance in older subjects.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30003904},
      UT           = {WOS:000450540800053},
      doi          = {10.1016/j.neuropsychologia.2018.07.006},
      url          = {https://juser.fz-juelich.de/record/850281},
}