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@ARTICLE{Hlukhova:850675,
      author       = {Hlukhova, H. and Menger, M. and Offenhäusser, A. and
                      Vitusevich, S.},
      title        = {{H}ighly {S}ensitive {A}ptamer-{B}ased {M}ethod for the
                      {D}etection of {C}ardiac {B}iomolecules on {S}ilicon
                      {D}ioxide {S}urfaces},
      journal      = {MRS advances},
      volume       = {3},
      number       = {27},
      issn         = {2059-8521},
      address      = {Cambridge},
      publisher    = {Cambridge University Press},
      reportid     = {FZJ-2018-04483},
      pages        = {1535 - 1541},
      year         = {2018},
      abstract     = {In this work, we report on fabrication of the thin-films of
                      silicon oxide dielectric layers on silicon with back-side
                      contact and utilization of the structure to study the
                      detection of human Troponin antigen (cTnI) molecules: the
                      cardiac biomarkers for the early diagnosis of acute
                      myocardial infraction. Aptamers are selectively bound to the
                      target molecules and can block the binding epitope for
                      further reaction like immobilization or interaction to any
                      other molecules. In contrast to antibodies, the aptamers are
                      smaller in size, which allows target molecules to be brought
                      closer to the surface of the biosensor and, therefore, to
                      enhance the molecular signal. The target molecule in this
                      work is cTnI, which is located in the cardiac muscle tissue.
                      As a reliable indicator of heart failure and injury, it is
                      specifically considered for the diagnosis of myocardial
                      infarctions. The solutions of Troponin molecules were
                      studied in different concentrations range from 10 pg/μL to
                      1 ng/μL. For the electrical detection of cTnI, we used the
                      field-effect capacitive electrolyte-insulator-semiconductor
                      (EIS) technique, which is a robust method for the
                      quantitative characterization of molecular layers. The
                      measured values of capacitances and flat band voltages were
                      used to acquire information about the properties of the
                      molecular layers obtained using solutions with different
                      troponin concentrations. It was shown that this method
                      demonstrates high sensitivity to target cardiac biomolecules
                      and opens up new perspectives for highly selective and
                      sensitive cardiac biosensors developed on the basis of
                      silicon nanowire structures.},
      cin          = {ICS-8},
      ddc          = {670},
      cid          = {I:(DE-Juel1)ICS-8-20110106},
      pnm          = {523 - Controlling Configuration-Based Phenomena (POF3-523)},
      pid          = {G:(DE-HGF)POF3-523},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000432480200005},
      doi          = {10.1557/adv.2018.332},
      url          = {https://juser.fz-juelich.de/record/850675},
}