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@ARTICLE{Hagelweide:850708,
      author       = {Hagelweide, Klara and Schönberger, Anna R. and Kracht,
                      Lutz W. and Gründler, Theo O. J. and Fink, Gereon R. and
                      Schubotz, Ricarda I.},
      title        = {{M}otor cognition in patients treated with subthalamic
                      nucleus deep brain stimulation: {L}imits of compensatory
                      overactivity in {P}arkinson's disease},
      journal      = {Neuropsychologia},
      volume       = {117},
      issn         = {0028-3932},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2018-04511},
      pages        = {491 - 499},
      year         = {2018},
      abstract     = {Recent fMRI findings revealed that impairment in a serial
                      prediction task in patients suffering from Parkinson's
                      disease (PD) results from hypoactivity of the SMA.
                      Furthermore, hyperactivity of the lateral premotor cortex
                      sustained performance after withdrawal of medication. To
                      further explore these findings, we here examined the impact
                      of deep brain stimulation of the subthalamic nucleus on the
                      activity of the putamen and premotor areas while performing
                      the serial prediction task. To this end, we measured eight
                      male PD patients ON and OFF deep brain stimulation and eight
                      healthy age-matched male controls using [15O] water positron
                      emission tomography to measure regional cerebral blood flow.
                      As expected, PD patients showed poorer performance than
                      healthy controls while performance did not differ between
                      OFF and ON stimulation. Hypoactivity of the putamen and
                      hyperactivity of the left lateral premotor cortex was found
                      in patients compared to controls. Lateral premotor
                      hyperactivity further increased OFF compared to ON
                      stimulation and was positively related to task performance.
                      These results confirm that the motor loop's dysfunction has
                      impact on cognitive processes (here: prediction of serial
                      stimuli) in PD. Extending prior data regarding the role of
                      the lateral premotor cortex in cognitive compensation, our
                      results indicate that lateral premotor cortex hyperactivity,
                      while beneficial in moderate levels of impairment, might
                      fail to preserve performance in more severe stages of the
                      motor loop's degeneration.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30003903},
      UT           = {WOS:000450540800050},
      doi          = {10.1016/j.neuropsychologia.2018.07.007},
      url          = {https://juser.fz-juelich.de/record/850708},
}