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000850822 1001_ $$0P:(DE-HGF)0$$aPoeppl, Timm B.$$b0$$eCorresponding author
000850822 245__ $$aA view behind the mask of sanity: meta-analysis of aberrant brain activity in psychopaths
000850822 260__ $$aLondon$$bMacmillan$$c2019
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000850822 500__ $$aPTF is supported by the National Institute of Mental Health  (R01-MH074457).  DB  is  funded  by  the  Deutsche  Forschungsgemeinschaft (DFG, BZ2/2-1, BZ2/3-1, and BZ2/4-1; International Research Training Group IRTG2150), Amazon AWS Research Grant, the German National Academic Foundation, and the START-Program of the Faculty of Medicine, RWTH Aachen. SBE is supported by the Deutsche Forschungsgemeinschaft (DFG, EI 816/4-1, EI 816/6-1), the National Institute of Mental Health (R01-MH074457), the Helmholtz Portfolio Theme “Supercomputing and Modeling for the Human Brain,” and the European Union’ s Horizon 2020 Research and Innovation Programme under Grant Agreement No. 7202070 (HBP SGA1)Gebühren ergänzt am 04.10.18
000850822 520__ $$aPsychopathy is a disorder of high public concern because it predicts violence and offense recidivism. Recent brain imaging studies suggest abnormal brain activity underlying psychopathic behavior. No reliable pattern of altered neural activity has been disclosed so far. This study sought to identify consistent changes of brain activity in psychopaths and to investigate whether these could explain known psychopathology. First, we used activation likelihood estimation (p < 0.05, corrected) to meta-analyze brain activation changes associated with psychopathy across 28 functional magnetic resonance imaging studies reporting 753 foci from 155 experiments. Second, we characterized the ensuing regions functionally by employing metadata of a large-scale neuroimaging database (p < 0.05, corrected). Psychopathy was consistently associated with decreased brain activity in the right laterobasal amygdala, the dorsomedial prefrontal cortex, and bilaterally in the lateral prefrontal cortex. A robust increase of activity was observed in the fronto-insular cortex on both hemispheres. Data-driven functional characterization revealed associations with semantic language processing (left lateral prefrontal and fronto-insular cortex), action execution and pain processing (right lateral prefrontal and left fronto-insular), social cognition (dorsomedial prefrontal cortex), and emotional as well as cognitive reward processing (right amygdala and fronto-insular cortex). Aberrant brain activity related to psychopathy is located in prefrontal, insular, and limbic regions. Physiological mental functions fulfilled by these brain regions correspond to disturbed behavioral patterns pathognomonic for psychopathy. Hence, aberrant brain activity may not just be an epiphenomenon of psychopathy but directly related to the psychopathology of this disorder.
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000850822 7001_ $$0P:(DE-HGF)0$$aDonges, Maximilian R.$$b1
000850822 7001_ $$00000-0002-9706-0928$$aMokros, Andreas$$b2
000850822 7001_ $$0P:(DE-HGF)0$$aRupprecht, Rainer$$b3
000850822 7001_ $$0P:(DE-HGF)0$$aFox, Peter T.$$b4
000850822 7001_ $$0P:(DE-HGF)0$$aLaird, Angela R.$$b5
000850822 7001_ $$0P:(DE-Juel1)136848$$aBzdok, Danilo$$b6
000850822 7001_ $$0P:(DE-HGF)0$$aLangguth, Berthold$$b7
000850822 7001_ $$0P:(DE-Juel1)131678$$aEickhoff, Simon$$b8$$ufzj
000850822 773__ $$0PERI:(DE-600)1502531-7$$a10.1038/s41380-018-0122-5$$p463–470$$tMolecular psychiatry$$v24$$x1476-5578$$y2019
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