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@ARTICLE{Barnsley:850823,
      author       = {Barnsley, Lester and Gray, Michael D. and Beguin, Estelle
                      and Carugo, Dario and Stride, Eleanor},
      title        = {{A} {C}ombined {M}agnetic-{A}coustic {D}evice for
                      {S}imultaneous, {C}oaligned {A}pplication of {M}agnetic and
                      {U}ltrasonic {F}ields},
      journal      = {Advanced materials technologies},
      volume       = {3},
      number       = {7},
      issn         = {2365-709X},
      address      = {Weinheim},
      publisher    = {Wiley},
      reportid     = {FZJ-2018-04594},
      pages        = {1800081 -},
      year         = {2018},
      abstract     = {Acoustically‐responsive microbubbles have been widely
                      researched as agents for both diagnostic and therapeutic
                      applications of ultrasound. There has also been considerable
                      interest in magnetically‐functionalised microbubbles as
                      multi‐modality imaging agents and carriers for targeted
                      drug delivery. In this paper, we present a design for an
                      integrated device capable of generating co‐aligned
                      magnetic and acoustic fields in order to accumulate
                      microbubbles at a specific location and to activate them
                      acoustically. For this proof‐of‐concept study, the
                      device was designed to concentrate microbubbles at a
                      distance of 10 mm from the probe's surface, commensurate
                      with relevant tissue depths in preclinical small animal
                      models. Previous studies have indicated that both
                      microbubble concentration and duration of cavitation
                      activity are positively correlated with therapeutic effect.
                      The utility of the device was assessed in vitro tests in a
                      tissue‐mimicking phantom containing a single vessel (1.2
                      mm diameter). At a peak fluid velocity of 4.2 mm s−1
                      microbubble accumulation was observed under B‐mode
                      ultrasound imaging and the corresponding cavitation activity
                      was sustained for a period more than 4 times longer than
                      that achieved with an identical acoustic field but in the
                      absence of a magnet. The feasibility of developing a larger
                      scale device for human applications is discussed.},
      cin          = {JCNS-FRM-II / Neutronenstreuung ; JCNS-1},
      ddc          = {600},
      cid          = {I:(DE-Juel1)JCNS-FRM-II-20110218 /
                      I:(DE-Juel1)JCNS-1-20110106},
      pnm          = {6G4 - Jülich Centre for Neutron Research (JCNS) (POF3-623)
                      / 6G15 - FRM II / MLZ (POF3-6G15)},
      pid          = {G:(DE-HGF)POF3-6G4 / G:(DE-HGF)POF3-6G15},
      experiment   = {EXP:(DE-MLZ)NOSPEC-20140101},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000438336800015},
      doi          = {10.1002/admt.201800081},
      url          = {https://juser.fz-juelich.de/record/850823},
}