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@INPROCEEDINGS{Galldiks:850909,
      author       = {Galldiks, Norbert and Unterrainer, M. and Judov, N. and
                      Stoffels, G. and Lohmann, P. and Vettermann, F. and Dunkl,
                      V. and Suchorska, B. and Tonn, J. C. and Kreth, F. W. and
                      Fink, G. R. and Bartenstein, P. and Langen, K. J. and
                      Albert, N. L.},
      title        = {{P}hotopenic defects on
                      {O}-(2-18{F}-fluoroethyl)-{L}-tyrosine {PET} - clinical
                      relevance in glioma patients.},
      reportid     = {FZJ-2018-04643},
      year         = {2018},
      abstract     = {V48Photopenic defects on O-(2-18F-fluoroethyl)-L-tyrosine
                      PET - clinical relevance in glioma patientsN. Galldiks1, M.
                      Unterrainer2, N. Judov3, G. Stoffels3, M. Rapp4, P.
                      Lohmann3, F. Vettermann2, V. Dunkl1, B. Suchorska5, J. C.
                      Tonn5, F. W. Kreth5, G. R. Fink1, P. Bartenstein2, K. J.
                      Langen3, N. L. Albert21Uniklinik Köln, Klinik für
                      Neurologie, Köln; 2Uniklinik München (LMU), Klinik für
                      Nuklearmedizin, München; 3Forschungszentrum Jülich, Inst.
                      für Neurowissenschaften und Medizin (INM-4), Jülich;
                      4Uniklinik Düsseldorf, Klinik für Neurochirurgie,
                      Düsseldorf; 5Uniklinik München (LMU), Klinik für
                      Neurochirurgie, MünchenZiel/Aim:In PET imaging, a fraction
                      of approximately $5-10\%$ of cerebral gliomas show no
                      increased accumulation of O-(2-18F-fluoroethyl)-L-tyrosine
                      (FET) compared to the normal brain. Some of these lesions
                      present even as photopenic defects. The clinical relevance
                      of this phenomenon remains to be
                      elucidated.Methodik/Methods:Glioma patients with a negative
                      FET PET scan prior to histological confirmation were
                      retrospectively identified in three university centers.
                      Gliomas were visually rated as having indifferent FET uptake
                      or as photopenic when FET uptake was below background
                      acitivity. For quantitative analysis, FET uptake in the area
                      of signal hyperintensity on the T2-/FLAIR-weighted MRI was
                      evaluated by mean standardized uptake values (SUV) and mean
                      tumor-to-brain ratios (TBR). In patients without treatment
                      (“watch and wait” strategy), the progression-free
                      survival (PFS) of photopenic gliomas was compared with that
                      of gliomas with indifferent FET uptake.Ergebnisse/Results:Of
                      104 FET-negative gliomas (2 WHO grade I, 75 WHO grade II, 23
                      WHO grade III, and 4 WHO grade IV), 36 cases with photopenic
                      defects $(35\%)$ were identified (23 WHO grade II, 12 WHO
                      grade III, and one glioblastoma). FET uptake in photopenic
                      defects was significantly decreased compared to both the
                      healthy-appearing brain tissue (SUV, 0.88±0.23 vs.
                      1.10±0.26; P<0.001) and gliomas with indifferent FET uptake
                      (TBR, 0.83±0.10 vs. 1.03±0.11; P<0.001). In patients
                      without treatment (all WHO grade II; stereotactic biopsy
                      only), PFS of those with indifferent FET uptake (n=16) was
                      significantly longer than with photopenic defects (n=10) (31
                      vs. 23 months; P=0.026). Patients’ age and rate of IDH
                      mutations did not differ significantly
                      (P>0.05).Schlussfolgerungen/Conclusions:Around one-third of
                      FET-negative gliomas exhibit photopenic defects. These
                      photopenic gliomas should be managed more actively as they
                      might have a higher risk for harboring a higher-grade glioma
                      and an unfavorable outcome compared to gliomas with
                      indifferent FET uptake.},
      month         = {Apr},
      date          = {2018-04-18},
      organization  = {Jahrestagung der Deutschen
                       Gesellschaft für Nuklearmedizin 2018,
                       Bremen (Germany), 18 Apr 2018 - 21 Apr
                       2018},
      cin          = {INM-3 / INM-4},
      cid          = {I:(DE-Juel1)INM-3-20090406 / I:(DE-Juel1)INM-4-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)1},
      url          = {https://juser.fz-juelich.de/record/850909},
}