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@ARTICLE{Dafsari:851195,
      author       = {Dafsari, Haidar S. and Chaudhuri, K. Ray and Mahlstedt,
                      Picabo and Sachse, Lena and Steffen, Julia K. and
                      Petry-Schmelzer, Jan Niklas and Dembek, Till A. and Reker,
                      Paul and Barbe, Michael and Visser-Vandewalle, Veerle and
                      Fink, Gereon R. and Timmermann, Lars},
      title        = {{B}eneficial effects of bilateral subthalamic stimulation
                      on alexithymia in {P}arkinson's disease},
      journal      = {European journal of neurology},
      volume       = {26},
      number       = {2},
      issn         = {1351-5101},
      address      = {Oxford},
      publisher    = {Blackwell Science91133},
      reportid     = {FZJ-2018-04895},
      pages        = {222-e17},
      year         = {2019},
      abstract     = {Background and purposeSubthalamic nucleus (STN) deep brain
                      stimulation (DBS) improves quality of life (QoL) and motor
                      and non‐motor symptoms in advanced Parkinson's disease
                      (PD). However, its effect on alexithymia and its
                      relationship to other neuropsychiatric symptoms and QoL in
                      PD is unclear.MethodsIn this prospective, observational
                      study of 39 patients with PD undergoing STN‐DBS, we
                      examined the Parkinson's Disease Questionnaire‐8
                      (PDQ‐8), 20‐item Toronto Alexithymia Scale (TAS‐20),
                      Hospital Anxiety and Depression Scale (HADS), Self‐Report
                      Manic Inventory (SRMI), Apathy Evaluation Scale (AES),
                      Unified Parkinson's Disease Rating Scale (UPDRS) activities
                      of daily living, UPDRS motor examination and UPDRS
                      complications (UPDRS‐II/‐III/‐IV) and
                      levodopa‐equivalent daily dose (LEDD) pre‐operatively
                      and at 5‐month follow‐up. Outcome changes were tested
                      with Wilcoxon signed‐rank or paired t‐test when
                      parametric tests were applicable and corrected for multiple
                      comparisons. The relationship between outcome changes was
                      explored with bivariate correlations. Additionally, partial
                      correlations between PDQ‐8 and TAS‐20 were computed
                      controlling for HADS, SRMI and AES change scores. Predictor
                      analyses for PDQ‐8 improvement were calculated for all
                      baseline parameters.ResultsThe baseline prevalence of
                      alexithymia was $17.9\%.$ We observed significant beneficial
                      effects of STN‐DBS on PDQ‐8, TAS‐20, HADS, UPDRS‐II,
                      ‐III and ‐IV scores and significant LEDD reduction. The
                      correlation between TAS‐20 and PDQ‐8 improvements
                      remained significant after controlling for all other
                      aforementioned outcomes. Predictor analyses for PDQ‐8
                      improvement were significant for PDQ‐8 and
                      TAS‐20.ConclusionsThis is the first report of beneficial
                      effects of STN‐DBS on alexithymia. Alexithymia was
                      significantly associated with QoL outcome independent of
                      anxiety, depression, mania and apathy. Our study highlights
                      the importance of alexithymia for holistic assessments of
                      DBS outcomes.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30107062},
      UT           = {WOS:000455803800006},
      doi          = {10.1111/ene.13773},
      url          = {https://juser.fz-juelich.de/record/851195},
}