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@ARTICLE{Abraham:851323,
      author       = {Abraham, Jella-Andrea and Linnartz, Christina and Dreissen,
                      Georg and Springer, Ronald and Blaschke, Stefan and Rueger,
                      Maria A. and Fink, Gereon R. and Hoffmann, Bernd and Merkel,
                      Rudolf},
      title        = {{D}irecting neuronal outgrowth and network formation of rat
                      cortical neurons by cyclic substrate stretch},
      journal      = {Langmuir},
      volume       = {35},
      number       = {23},
      issn         = {1520-5827},
      address      = {Washington, DC},
      publisher    = {ACS Publ.},
      reportid     = {FZJ-2018-05009},
      pages        = {7423-7431},
      year         = {2019},
      abstract     = {Neuronal mechanobiology plays a vital function in brain
                      development and homeostasis with an essential role in
                      neuronal maturation, pathfinding, and differentiation but is
                      also crucial for understanding brain pathology. In this
                      study, we constructed an in vitro system to assess neuronal
                      responses to cyclic strain as a mechanical signal. The
                      selected strain amplitudes mimicked physiological as well as
                      pathological conditions. By subjecting embryonic neuronal
                      cells to cyclic uniaxial strain we could steer the direction
                      of neuronal outgrowth perpendicular to strain direction for
                      all applied amplitudes. A long-term analysis proved
                      maintained growth direction. Moreover, stretched neurons
                      showed an enhanced length, growth, and formation of nascent
                      side branches with most elevated growth rates subsequent to
                      physiological straining. Application of cyclic strain to
                      already formed neurites identified retraction bulbs with
                      destabilized microtubule structures as spontaneous
                      responses. Importantly, neurons were able to adapt to the
                      mechanical signals without induction of cell death and
                      showed a triggered growth behavior when compared to
                      unstretched neurons. The data suggest that cyclic strain
                      plays a critical role in neuronal development.},
      cin          = {INM-3 / ICS-7},
      ddc          = {670},
      cid          = {I:(DE-Juel1)INM-3-20090406 / I:(DE-Juel1)ICS-7-20110106},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572) / 552 -
                      Engineering Cell Function (POF3-552)},
      pid          = {G:(DE-HGF)POF3-572 / G:(DE-HGF)POF3-552},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30110535},
      UT           = {WOS:000471728600013},
      doi          = {10.1021/acs.langmuir.8b02003},
      url          = {https://juser.fz-juelich.de/record/851323},
}