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@ARTICLE{Ali:851327,
author = {Ali, Sharib and Wörz, Stefan and Amunts, Katrin and Eils,
Roland and Axer, Markus and Rohr, Karl},
title = {{R}igid and non-rigid registration of polarized light
imaging data for 3{D} reconstruction of the temporal lobe of
the human brain at micrometer resolution},
journal = {NeuroImage},
volume = {181},
issn = {1053-8119},
address = {Orlando, Fla.},
publisher = {Academic Press},
reportid = {FZJ-2018-05013},
pages = {235-251},
year = {2018},
abstract = {To understand the spatial organization as well as long- and
short-range connections of the human brain at microscopic
resolution, 3D reconstruction of histological sections is
important. We approach this challenge by reconstructing
series of unstained histological sections of multi-scale
(1:3 μm and 64 μm) and multi-modal 3D polarized light
imaging (3D-PLI) data. Since spatial coherence is lost
during the sectioning procedure, image registration is the
major step in 3D reconstruction. We propose a non-rigid
registration method which comprises of a novel multi-modal
similarity metric and an improved regularization scheme to
cope with deformations inevitably introduced during the
sectioning procedure, as well as a rigid registration
approach using a robust similarity metric for improved
initial alignment. We also introduce a multi-scale
feature-based localization and registration approach for
mapping of 1:3 μm sections to 64 μm sections and a
scale-adaptive method that can handle challenging sections
with large semi-global deformations due to tissue splits. We
have applied our registration method to 126 consecutive
sections of the temporal lobe of the human brain with 64 μm
and 1:3 μm resolution. Each step of the registration method
was quantitatively evaluated using 10 different sections and
manually determined ground truth, and a quantitative
comparison with previous methods was performed. Visual
assessment of the reconstructed volumes and comparison with
reference volumes confirmed the high quality of the
registration result.},
cin = {INM-1 / JARA-HPC},
ddc = {610},
cid = {I:(DE-Juel1)INM-1-20090406 / $I:(DE-82)080012_20140620$},
pnm = {571 - Connectivity and Activity (POF3-571) / HBP SGA2 -
Human Brain Project Specific Grant Agreement 2 (785907) /
SMHB - Supercomputing and Modelling for the Human Brain
(HGF-SMHB-2013-2017) / 3D Reconstruction of Nerve Fibers in
the Human, the Monkey and the Rodent Brain
$(jinm11_20171101)$},
pid = {G:(DE-HGF)POF3-571 / G:(EU-Grant)785907 /
G:(DE-Juel1)HGF-SMHB-2013-2017 /
$G:(DE-Juel1)jinm11_20171101$},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:30018015},
UT = {WOS:000445165600021},
doi = {10.1016/j.neuroimage.2018.06.084},
url = {https://juser.fz-juelich.de/record/851327},
}